P49721: Proteasome subunit beta type-2

General Information

Protein names	- Proteasome subunit beta type-2 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - Macropain subunit C7-I - Multicatalytic endopeptidase complex subunit C7-I - Proteasome component C7-I
Gene names	PSMB2
Organism	Homo sapiens
Protease Family
Protease ID	T01.984
Chromosome location
UniProt ID	P49721

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEYLIGIQGP DYVLVASDRV AASNIVQMKD DHDKMFKMSE KILLLCVGEA GDTVQFAEYI
        70         80         90        100        110        120
QKNVQLYKMR NGYELSPTAA ANFTRRNLAD CLRSRTPYHV NLLLAGYDEH EGPALYYMDY
       130        140        150        160        170        180
LAALAKAPFA AHGYGAFLTL SILDRYYTPT ISRERAVELL RKCLEELQKR FILNLPTFSV
       190        200
RIIDKNGIHD LDNISFPKQG S

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49721-1-Acetylation	MEYLIG...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49721-1-Acetylation	MEYLIG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49721-1-Acetylation	MEYLIG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49721-1-Acetylation	MEYLIG...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49721-71-acetylation	NGYELS...	71	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49721-72-	GYELSP...	72			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49721-187-	GIHDLD...	187			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49721-187-	GIHDLD...	187			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49721-187-	GIHDLD...	187			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49721-190-unknown	DLDNIS...	190		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17681

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KNGIHD	189	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17681
	...PKQGS	201	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	189	GIHD.\|.DLDN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)