P49790: Nuclear pore complex protein Nup153

General Information

Protein names	- Nuclear pore complex protein Nup153 - 153 kDa nucleoporin - Nucleoporin Nup153
Gene names	NUP153
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49790

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGAGGVGG GGGGKIRTRR CHQGPIKPYQ QGRQQHQGIL SRVTESVKNI VPGWLQRYFN
        70         80         90        100        110        120
KNEDVCSCST DTSEVPRWPE NKEDHLVYAD EESSNITDGR ITPEPAVSNT EEPSTTSTAS
       130        140        150        160        170        180
NYPDVLTRPS LHRSHLNFSM LESPALHCQP STSSAFPIGS SGFSLVKEIK DSTSQHDDDN
       190        200        210        220        230        240
ISTTSGFSSR ASDKDITVSK NTSLPPLWSP EAERSHSLSQ HTATSSKKPA FNLSAFGTLS
       250        260        270        280        290        300
PSLGNSSILK TSQLGDSPFY PGKTTYGGAA AAVRQSKLRN TPYQAPVRRQ MKAKQLSAQS
       310        320        330        340        350        360
YGVTSSTARR ILQSLEKMSS PLADAKRIPS IVSSPLNSPL DRSGIDITDF QAKREKVDSQ
       370        380        390        400        410        420
YPPVQRLMTP KPVSIATNRS VYFKPSLTPS GEFRKTNQRI DNKCSTGYEK NMTPGQNREQ
       430        440        450        460        470        480
RESGFSYPNF SLPAANGLSS GVGGGGGKMR RERTRFVASK PLEEEEMEVP VLPKISLPIT
       490        500        510        520        530        540
SSSLPTFNFS SPEITTSSPS PINSSQALTN KVQMTSPSST GSPMFKFSSP IVKSTEANVL
       550        560        570        580        590        600
PPSSIGFTFS VPVAKTAELS GSSSTLEPII SSSAHHVTTV NSTNCKKTPP EDCEGPFRPA
       610        620        630        640        650        660
EILKEGSVLD ILKSPGFASP KIDSVAAQPT ATSPVVYTRP AISSFSSSGI GFGESLKAGS
       670        680        690        700        710        720
SWQCDTCLLQ NKVTDNKCIA CQAAKLSPRD TAKQTGIETP NKSGKTTLSA SGTGFGDKFK
       730        740        750        760        770        780
PVIGTWDCDT CLVQNKPEAI KCVACETPKP GTCVKRALTL TVVSESAETM TASSSSCTVT
       790        800        810        820        830        840
TGTLGFGDKF KRPIGSWECS VCCVSNNAED NKCVSCMSEK PGSSVPASSS STVPVSLPSG
       850        860        870        880        890        900
GSLGLEKFKK PEGSWDCELC LVQNKADSTK CLACESAKPG TKSGFKGFDT SSSSSNSAAS
       910        920        930        940        950        960
SSFKFGVSSS SSGPSQTLTS TGNFKFGDQG GFKIGVSSDS GSINPMSEGF KFSKPIGDFK
       970        980        990       1000       1010       1020
FGVSSESKPE EVKKDSKNDN FKFGLSSGLS NPVSLTPFQF GVSNLGQEEK KEELPKSSSA
      1030       1040       1050       1060       1070       1080
GFSFGTGVIN STPAPANTIV TSENKSSFNL GTIETKSASV APFTCKTSEA KKEEMPATKG
      1090       1100       1110       1120       1130       1140
GFSFGNVEPA SLPSASVFVL GRTEEKQQEP VTSTSLVFGK KADNEEPKCQ PVFSFGNSEQ
      1150       1160       1170       1180       1190       1200
TKDENSSKST FSFSMTKPSE KESEQPAKAT FAFGAQTSTT ADQGAAKPVF SFLNNSSSSS
      1210       1220       1230       1240       1250       1260
STPATSAGGG IFGSSTSSSN PPVATFVFGQ SSNPVSSSAF GNTAESSTSQ SLLFSQDSKL
      1270       1280       1290       1300       1310       1320
ATTSSTGTAV TPFVFGPGAS SNNTTTSGFG FGATTTSSSA GSSFVFGTGP SAPSASPAFG
      1330       1340       1350       1360       1370       1380
ANQTPTFGQS QGASQPNPPG FGSISSSTAL FPTGSQPAPP TFGTVSSSSQ PPVFGQQPSQ
      1390       1400       1410       1420       1430       1440
SAFGSGTTPN SSSAFQFGSS TTNFNFTNNS PSGVFTFGAN SSTPAASAQP SGSGGFPFNQ
      1450       1460       1470
SPAAFTVGSN GKNVFSSSGT SFSGRKIKTA VRRRK

Isoforms

- Isoform 2 of Nuclear pore complex protein Nup153 - Isoform 3 of Nuclear pore complex protein Nup153

Sequence View

        10         20         30         40         50         60
MASGAGGVGG GGGGKIRTRR CHQGPIKPYQ QGRQQHQGIL SRVTESVKNI VPGWLQRYFN
        70         80         90        100        110        120
KNEDVCSCST DTSEVPRWPE NKEDHLVYAD EESSNITDGR ITPEPAVSNT EEPSTTSTAS
       130        140        150        160        170        180
NYPDVLTRPS LHRSHLNFSM LESPALHCQP STSSAFPIGS SGFSLVKEIK DSTSQHDDDN
       190        200        210        220        230        240
ISTTSGFSSR ASDKDITVSK NTSLPPLWSP EAERSHSLSQ HTATSSKKPA FNLSAFGTLS
       250        260        270        280        290        300
PSLGNSSILK TSQLGDSPFY PGKTTYGGAA AAVRQSKLRN TPYQAPVRRQ MKAKQLSAQS
       310        320        330        340        350        360
YGVTSSTARR ILQSLEKMSS PLADAKRIPS IVSSPLNSPL DRSGIDITDF QAKREKVDSQ
       370        380        390        400        410        420
YPPVQRLMTP KPVSIATNRS VYFKPSLTPS GEFRKTNQRI DNKCSTGYEK NMTPGQNREQ
       430        440        450        460        470        480
RESGFSYPNF SLPAANGLSS GVGGGGGKMR RERTRFVASK PLEEEEMEVP VLPKISLPIT
       490        500        510        520        530        540
SSSLPTFNFS SPEITTSSPS PINSSQALTN KVQMTSPSST GSPMFKFSSP IVKSTEANVL
       550        560        570        580        590        600
PPSSIGFTFS VPVAKTAELS GSSSTLEPII SSSAHHVTTV NSTNCKKTPP EDCEGPFRPA
       610        620        630        640        650        660
EILKEGSVLD ILKSPGFASP KIDSVAAQPT ATSPVVYTRP AISSFSSSGI GFGESLKAGS
       670        680        690        700        710        720
SWQCDTCLLQ NKVTDNKCIA CQAAKLSPRD TAKQTGIETP NKSGKTTLSA SGTGFGDKFK
       730        740        750        760        770        780
PVIGTWDCDT CLVQNKPEAI KCVACETPKP GTCVKRALTL TVVSESAETM TASSSSCTVT
       790        800        810        820        830        840
TGTLGFGDKF KRPIGSWECS VCCVSNNAED NKCVSCMSEK PGSSVPASSS STVPVSLPSG
       850        860        870        880        890        900
GSLGLEKFKK PEGSWDCELC LVQNKADSTK CLACESAKPG TKSGFKGFDT SSSSSNSAAS
       910        920        930        940        950        960
SSFKFGVSSS SSGPSQTLTS TGNFKFGDQG GFKIGVSSDS GSINPMSEGF KFSKPIGDFK
       970        980        990       1000       1010       1020
FGVSSESKPE EVKKDSKNDN FKFGLSSGLS NPVSLTPFQF GVSNLGQEEK KEELPKSSSA
      1030       1040       1050       1060       1070       1080
GFSFGTGVIN STPAPANTIV TSENKSSFNL GTIETKSASV APFTCKTSEA KKEEMPATKG
      1090       1100       1110       1120       1130       1140
GFSFGNVEPA SLPSASVFVL GRTEEKQQEP VTSTSLVFGK KADNEEPKCQ PVFSFGNSEQ
      1150       1160       1170       1180       1190       1200
TKDENSSKST FSFSMTKPSE KESEQPAKAT FAFGAQTSTT ADQGAAKPVF SFLNNSSSSS
      1210       1220       1230       1240       1250       1260
STPATSAGGG IFGSSTSSSN PPVATFVFGQ SSNPVSSSAF GNTAESSTSQ SLLFSQDSKL
      1270       1280       1290       1300       1310       1320
ATTSSTGTAV TPFVFGPGAS SNNTTTSGFG FGATTTSSSA GSSFVFGTGP SAPSASPAFG
      1330       1340       1350       1360       1370       1380
ANQTPTFGQS QGASQPNPPG FGSISSSTAL FPTGSQPAPP TFGTVSSSSQ PPVFGQQPSQ
      1390       1400       1410       1420       1430       1440
SAFGSGTTPN SSSAFQFGSS TTNFNFTNNS PSGVFTFGAN SSTPAASAQP SGSGGFPFNQ
      1450       1460       1470
SPAAFTVGSN GKNVFSSSGT SFSGRKIKTA VRRRK         10         20         30         40         50         60
MASGAGGVGG GGGGKIRTRR CHQGPIKPYQ QGRQQHQGIL SRVTESVKNI VPGWLQRYFN
        70         80         90        100        110        120
KNEDVCSCST DTSEVPRWPE NKEDHLVYAD EESSNITDGR ITPEPAVSNT EEPSTTSTAS
       130        140        150        160        170        180
NYPDVLTRPS LHRSHLNFSM LESPALHCQP STSSAFPIGS SGFSLVKEIK DSTSQHDDDN
       190        200        210        220        230        240
ISTTSGFSSR ASDKDITVSK NTSLPPLWSP EAERSHSLSQ HTATSSKKPA FNLSAFGTLS
       250        260        270        280        290        300
PSLGNSSILK TSQLGDSPFY PGKTTYGGAA AAVRQSKLRN TPYQAPVRRQ MKAKQLSAQS
       310        320        330        340        350        360
YGVTSSTARR ILQSLEKMSS PLADAKRIPS IVSSPLNSPL DRSGIDITDF QAKREKVDSQ
       370        380        390        400        410        420
YPPVQRLMTP KPVSIATNRS VYFKPSLTPS GEFRKTNQRI DNKCSTGYEK NMTPGQNREQ
       430        440        450        460        470        480
RESGFSYPNF SLPAANGLSS GVGGGGGKMR RERTRFVASK PLEEEEMEVP VLPKISLPIT
       490        500        510        520        530        540
SSSLPTFNFS SPEITTSSPS PINSSQALTN KVQMTSPSST GSPMFKFSSP IVKSTEANVL
       550        560        570        580        590        600
PPSSIGFTFS VPVAKTAELS GSSSTLEPII SSSAHHVTTV NSTNCKKTPP EDCEGPFRPA
       610        620        630        640        650        660
EILKEGSVLD ILKSPGFASP KIDSVAAQPT ATSPVVYTRP AISSFSSSGI GFGESLKAGS
       670        680        690        700        710        720
SWQCDTCLLQ NKVTDNKCIA CQAAKLSPRD TAKQTGIETP NKSGKTTLSA SGTGFGDKFK
       730        740        750        760        770        780
PVIGTWDCDT CLVQNKPEAI KCVACETPKP GTCVKRALTL TVVSESAETM TASSSSCTVT
       790        800        810        820        830        840
TGTLGFGDKF KRPIGSWECS VCCVSNNAED NKCVSCMSEK PGSSVPASSS STVPVSLPSG
       850        860        870        880        890        900
GSLGLEKFKK PEGSWDCELC LVQNKADSTK CLACESAKPG TKSGFKGFDT SSSSSNSAAS
       910        920        930        940        950        960
SSFKFGVSSS SSGPSQTLTS TGNFKFGDQG GFKIGVSSDS GSINPMSEGF KFSKPIGDFK
       970        980        990       1000       1010       1020
FGVSSESKPE EVKKDSKNDN FKFGLSSGLS NPVSLTPFQF GVSNLGQEEK KEELPKSSSA
      1030       1040       1050       1060       1070       1080
GFSFGTGVIN STPAPANTIV TSENKSSFNL GTIETKSASV APFTCKTSEA KKEEMPATKG
      1090       1100       1110       1120       1130       1140
GFSFGNVEPA SLPSASVFVL GRTEEKQQEP VTSTSLVFGK KADNEEPKCQ PVFSFGNSEQ
      1150       1160       1170       1180       1190       1200
TKDENSSKST FSFSMTKPSE KESEQPAKAT FAFGAQTSTT ADQGAAKPVF SFLNNSSSSS
      1210       1220       1230       1240       1250       1260
STPATSAGGG IFGSSTSSSN PPVATFVFGQ SSNPVSSSAF GNTAESSTSQ SLLFSQDSKL
      1270       1280       1290       1300       1310       1320
ATTSSTGTAV TPFVFGPGAS SNNTTTSGFG FGATTTSSSA GSSFVFGTGP SAPSASPAFG
      1330       1340       1350       1360       1370       1380
ANQTPTFGQS QGASQPNPPG FGSISSSTAL FPTGSQPAPP TFGTVSSSSQ PPVFGQQPSQ
      1390       1400       1410       1420       1430       1440
SAFGSGTTPN SSSAFQFGSS TTNFNFTNNS PSGVFTFGAN SSTPAASAQP SGSGGFPFNQ
      1450       1460       1470
SPAAFTVGSN GKNVFSSSGT SFSGRKIKTA VRRRK

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49790-1-unknown	MASGAG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83477
P49790-2-unknown	MASGAG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49790-2-Acetylation	ASGAGG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49790-2-Acetylation	ASGAGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49790-2-Acetylation	ASGAGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49790-2-Acetylation	ASGAGG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49790-2-Acetylation	ASGAGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111244
P49790-91-unknown	EESSNI...	91		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11604
P49790-91-unknown	EESSNI...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141874
P49790-154-unknown	SAFPIG...	154		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175658
P49790-154-	SAFPIG...	154			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49790-350-unknown	FQAKRE...	350		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1888
P49790-350-unknown	FQAKRE...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150936
P49790-940-	SGSINP...	940			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49790-940-unknown	SGSINP...	940		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175660

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVYADE	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11604
...LVYADE	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125052
...IDITDF	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1888
...IDITDF	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134338
...VRRRK	1475	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VRRRK	1475	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79095

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	90	YADE.\|.EESS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	349	ITDF.\|.FQAK	inferred from experiment	unknown	MEROPS	Courvalin JC	Buendia B et al.:Caspase-dependent proteolysis o... (C14.003)	10318766,

TopFIND

P49790: Nuclear pore complex protein Nup153

General Information

9

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates