P51003: Poly(A) polymerase alpha

General Information

Protein names	- Poly(A) polymerase alpha - PAP-alpha - 2.7.7.19 - Polynucleotide adenylyltransferase alpha
Gene names	PAPOLA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51003

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG VFEEEEELQR
        70         80         90        100        110        120
RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA
       130        140        150        160        170        180
PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE
       190        200        210        220        230        240
DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI
       250        260        270        280        290        300
LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
       310        320        330        340        350        360
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK
       370        380        390        400        410        420
LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS
       430        440        450        460        470        480
FPAPKENPDK EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFEVD
       490        500        510        520        530        540
MKIAAMHVKR KQLHQLLPNH VLQKKKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS
       550        560        570        580        590        600
ATKTSPLNSS GSSQGRNSPA PAVTAASVTN IQATEVSVPQ VNSSESSGGT SSESIPQTAT
       610        620        630        640        650        660
QPAISPPPKP TVSRVVSSTR LVNPPPRSSG NAATSGNAAT KIPTPIVGVK RTSSPHKEES
       670        680        690        700        710        720
PKKTKTEEDE TSEDANCLAL SGHDKTEAKE QLDTETSTTQ SETIQTAASL LASQKTSSTD
       730        740
LSDIPALPAN PIPVIKNSIK LRLNR

Isoforms

- Isoform 2 of Poly(A) polymerase alpha

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51003-1-unknown	MPFPVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51003-1-unknown	MPFPVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84248
P51003-2-unknown	PFPVTT...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163288
P51003-2-unknown	PFPVTT...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51003-2-unmodified	PFPVTT...	2		other		CNRS/ISV	Large_scale_NTA_Human
P51003-7-unknown	TQGSQQ...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3817
P51003-7-unknown	TQGSQQ...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194774
P51003-251-unknown	MLVART...	251	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450534
P51003-251-unknown	MLVART...	251	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198460
P51003-632-	AATSGN...	632		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PFPVTT	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3817
...LCFDGI	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451267
...LCFDGI	163	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155161
...LSDIPA	725	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450534
...LRLNR	745	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	6	PVTT.\|.TQGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)