P51531: Probable global transcription activator SNF2L2
Protein names | - Probable global transcription activator SNF2L2 - 3.6.4.- - ATP-dependent helicase SMARCA2 - BRG1-associated factor 190B - BAF190B - Protein brahma homolog - hBRM - SNF2-alpha - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 {ECO:0000312|HGNC:HGNC:11098} |
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Gene names | SMARCA2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P51531 |
8
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM
70 80 90 100 110 120
GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY
130 140 150 160 170 180
MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH
190 200 210 220 230 240
QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ
250 260 270 280 290 300
QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA
310 320 330 340 350 360
AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL QARIAHRIQE
370 380 390 400 410 420
LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM RRDTTLETAL NSKAYKRSKR
430 440 450 460 470 480
QTLREARMTE KLEKQQKIEQ ERKRRQKHQE YLNSILQHAK DFKEYHRSVA GKIQKLSKAV
490 500 510 520 530 540
ATWHANTERE QKKETERIEK ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL
550 560 570 580 590 600
TNLVWEHKQA QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT
610 620 630 640 650 660
ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE SSRQETEEKI
670 680 690 700 710 720
LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS YYTVAHAISE RVEKQSALLI
730 740 750 760 770 780
NGTLKHYQLQ GLEWMVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK RLNGPYLIIV
790 800 810 820 830 840
PLSTLSNWTY EFDKWAPSVV KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL
850 860 870 880 890 900
AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH YVAPRRILLT GTPLQNKLPE LWALLNFLLP
910 920 930 940 950 960
TIFKSCSTFE QWFNAPFAMT GERVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVESQLPE
970 980 990 1000 1010 1020
KVEYVIKCDM SALQKILYRH MQAKGILLTD GSEKDKKGKG GAKTLMNTIM QLRKICNHPY
1030 1040 1050 1060 1070 1080
MFQHIEESFA EHLGYSNGVI NGAELYRASG KFELLDRILP KLRATNHRVL LFCQMTSLMT
1090 1100 1110 1120 1130 1140
IMEDYFAFRN FLYLRLDGTT KSEDRAALLK KFNEPGSQYF IFLLSTRAGG LGLNLQAADT
1150 1160 1170 1180 1190 1200
VVIFDSDWNP HQDLQAQDRA HRIGQQNEVR VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ
1210 1220 1230 1240 1250 1260
AGMFDQKSSS HERRAFLQAI LEHEEENEEE DEVPDDETLN QMIARREEEF DLFMRMDMDR
1270 1280 1290 1300 1310 1320
RREDARNPKR KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKIFGRGSRQ RRDVDYSDAL
1330 1340 1350 1360 1370 1380
TEKQWLRAIE DGNLEEMEEE VRLKKRKRRR NVDKDPAKED VEKAKKRRGR PPAEKLSPNP
1390 1400 1410 1420 1430 1440
PKLTKQMNAI IDTVINYKDR CNVEKVPSNS QLEIEGNSSG RQLSEVFIQL PSRKELPEYY
1450 1460 1470 1480 1490 1500
ELIRKPVDFK KIKERIRNHK YRSLGDLEKD VMLLCHNAQT FNLEGSQIYE DSIVLQSVFK
1510 1520 1530 1540 1550 1560
SARQKIAKEE ESEDESNEEE EEEDEEESES EAKSVKVKIK LNKKDDKGRD KGKGKKRPNR
1570 1580 1590
GKAKPVVSDF DSDEEQDERE QSEGSGTDDE
Isoforms
- Isoform Short of Probable global transcription activator SNF2L2Sequence View
10 20 30 40 50 60
MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM
70 80 90 100 110 120
GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY
130 140 150 160 170 180
MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH
190 200 210 220 230 240
QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ
250 260 270 280 290 300
QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA
310 320 330 340 350 360
AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL QARIAHRIQE
370 380 390 400 410 420
LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM RRDTTLETAL NSKAYKRSKR
430 440 450 460 470 480
QTLREARMTE KLEKQQKIEQ ERKRRQKHQE YLNSILQHAK DFKEYHRSVA GKIQKLSKAV
490 500 510 520 530 540
ATWHANTERE QKKETERIEK ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL
550 560 570 580 590 600
TNLVWEHKQA QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT
610 620 630 640 650 660
ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE SSRQETEEKI
670 680 690 700 710 720
LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS YYTVAHAISE RVEKQSALLI
730 740 750 760 770 780
NGTLKHYQLQ GLEWMVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK RLNGPYLIIV
790 800 810 820 830 840
PLSTLSNWTY EFDKWAPSVV KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL
850 860 870 880 890 900
AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH YVAPRRILLT GTPLQNKLPE LWALLNFLLP
910 920 930 940 950 960
TIFKSCSTFE QWFNAPFAMT GERVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVESQLPE
970 980 990 1000 1010 1020
KVEYVIKCDM SALQKILYRH MQAKGILLTD GSEKDKKGKG GAKTLMNTIM QLRKICNHPY
1030 1040 1050 1060 1070 1080
MFQHIEESFA EHLGYSNGVI NGAELYRASG KFELLDRILP KLRATNHRVL LFCQMTSLMT
1090 1100 1110 1120 1130 1140
IMEDYFAFRN FLYLRLDGTT KSEDRAALLK KFNEPGSQYF IFLLSTRAGG LGLNLQAADT
1150 1160 1170 1180 1190 1200
VVIFDSDWNP HQDLQAQDRA HRIGQQNEVR VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ
1210 1220 1230 1240 1250 1260
AGMFDQKSSS HERRAFLQAI LEHEEENEEE DEVPDDETLN QMIARREEEF DLFMRMDMDR
1270 1280 1290 1300 1310 1320
RREDARNPKR KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKIFGRGSRQ RRDVDYSDAL
1330 1340 1350 1360 1370 1380
TEKQWLRAIE DGNLEEMEEE VRLKKRKRRR NVDKDPAKED VEKAKKRRGR PPAEKLSPNP
1390 1400 1410 1420 1430 1440
PKLTKQMNAI IDTVINYKDR CNVEKVPSNS QLEIEGNSSG RQLSEVFIQL PSRKELPEYY
1450 1460 1470 1480 1490 1500
ELIRKPVDFK KIKERIRNHK YRSLGDLEKD VMLLCHNAQT FNLEGSQIYE DSIVLQSVFK
1510 1520 1530 1540 1550 1560
SARQKIAKEE ESEDESNEEE EEEDEEESES EAKSVKVKIK LNKKDDKGRD KGKGKKRPNR
1570 1580 1590
GKAKPVVSDF DSDEEQDERE QSEGSGTDDE
Protein Neighborhood
Domains & Features
8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P51531-1-unknown | MSTPTD... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P51531-1-unknown | MSTPTD... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt90011 | |||
P51531-581- | GEPIDE... | 581 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P51531-581-unknown | GEPIDE... | 581 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11629 | |||
P51531-581-unknown | GEPIDE... | 581 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154341 | |||
P51531-623- | MNPGYE... | 623 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P51531-623-unknown | MNPGYE... | 623 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168769 | |||
P51531-1289-unknown | AEVERL... | 1289 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11631 | |||
P51531-1289-unknown | AEVERL... | 1289 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157888 | |||
P51531-1319- | ALTEKQ... | 1319 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P51531-1319- | ALTEKQ... | 1319 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P51531-1319-unknown | ALTEKQ... | 1319 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168400 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ALGPDG | 580 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11629 | |||
...ALGPDG | 580 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137762 | |||
...IIKDDA | 1288 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11631 | |||
...IIKDDA | 1288 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141385 | |||
...GTDDE | 1590 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GTDDE | 1590 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt85629 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 580 | GPDG.|.GEPI | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 1288 | KDDA.|.AEVE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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