P51825: AF4/FMR2 family member 1

General Information

Protein names	- AF4/FMR2 family member 1 - ALL1-fused gene from chromosome 4 protein - Protein AF-4 - Protein FEL - Proto-oncogene AF4
Gene names	AFF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51825

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAQSSLYND DRNLLRIREK ERRNQEAHQE KEAFPEKIPL FGEPYKTAKG DELSSRIQNM
        70         80         90        100        110        120
LGNYEEVKEF LSTKSHTHRL DASENRLGKP KYPLIPDKGS SIPSSSFHTS VHHQSIHTPA
       130        140        150        160        170        180
SGPLSVGNIS HNPKMAQPRT EPMPSLHAKS CGPPDSQHLT QDRLGQEGFG SSHHKKGDRR
       190        200        210        220        230        240
ADGDHCASVT DSAPERELSP LISLPSPVPP LSPIHSNQQT LPRTQGSSKV HGSSNNSKGY
       250        260        270        280        290        300
CPAKSPKDLA VKVHDKETPQ DSLVAPAQPP SQTFPPPSLP SKSVAMQQKP TAYVRPMDGQ
       310        320        330        340        350        360
DQAPSESPEL KPLPEDYRQQ TFEKTDLKVP AKAKLTKLKM PSQSVEQTYS NEVHCVEEIL
       370        380        390        400        410        420
KEMTHSWPPP LTAIHTPSTA EPSKFPFPTK DSQHVSSVTQ NQKQYDTSSK THSNSQQGTS
       430        440        450        460        470        480
SMLEDDLQLS DSEDSDSEQT PEKPPSSSAP PSAPQSLPEP VASAHSSSAE SESTSDSDSS
       490        500        510        520        530        540
SDSESESSSS DSEENEPLET PAPEPEPPTT NKWQLDNWLT KVSQPAAPPE GPRSTEPPRR
       550        560        570        580        590        600
HPESKGSSDS ATSQEHSESK DPPPKSSSKA PRAPPEAPHP GKRSCQKSPA QQEPPQRQTV
       610        620        630        640        650        660
GTKQPKKPVK ASARAGSRTS LQGEREPGLL PYGSRDQTSK DKPKVKTKGR PRAAASNEPK
       670        680        690        700        710        720
PAVPPSSEKK KHKSSLPAPS KALSGPEPAK DNVEDRTPEH FALVPLTESQ GPPHSGSGSR
       730        740        750        760        770        780
TSGCRQAVVV QEDSRKDRLP LPLRDTKLLS PLRDTPPPQS LMVKITLDLL SRIPQPPGKG
       790        800        810        820        830        840
SRQRKAEDKQ PPAGKKHSSE KRSSDSSSKL AKKRKGEAER DCDNKKIRLE KEIKSQSSSS
       850        860        870        880        890        900
SSSHKESSKT KPSRPSSQSS KKEMLPPPPV SSSSQKPAKP ALKRSRREAD TCGQDPPKSA
       910        920        930        940        950        960
SSTKSNHKDS SIPKQRRVEG KGSRSSSEHK GSSGDTANPF PVPSLPNGNS KPGKPQVKFD
       970        980        990       1000       1010       1020
KQQADLHMRE AKKMKQKAEL MTDRVGKAFK YLEAVLSFIE CGIATESESQ SSKSAYSVYS
      1030       1040       1050       1060       1070       1080
ETVDLIKFIM SLKSFSDATA PTQEKIFAVL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH
      1090       1100       1110       1120       1130       1140
FESSSKVAQA PSPCIASTGT PSPLSPMPSP ASSVGSQSSA GSVGSSGVAA TISTPVTIQN
      1150       1160       1170       1180       1190       1200
MTSSYVTITS HVLTAFDLWE QAEALTRKNK EFFARLSTNV CTLALNSSLV DLVHYTRQGF
      1210
QQLQELTKTP

Isoforms

- Isoform 2 of AF4/FMR2 family member 1 - Isoform 3 of AF4/FMR2 family member 1

Sequence View

        10         20         30         40         50         60
MAAQSSLYND DRNLLRIREK ERRNQEAHQE KEAFPEKIPL FGEPYKTAKG DELSSRIQNM
        70         80         90        100        110        120
LGNYEEVKEF LSTKSHTHRL DASENRLGKP KYPLIPDKGS SIPSSSFHTS VHHQSIHTPA
       130        140        150        160        170        180
SGPLSVGNIS HNPKMAQPRT EPMPSLHAKS CGPPDSQHLT QDRLGQEGFG SSHHKKGDRR
       190        200        210        220        230        240
ADGDHCASVT DSAPERELSP LISLPSPVPP LSPIHSNQQT LPRTQGSSKV HGSSNNSKGY
       250        260        270        280        290        300
CPAKSPKDLA VKVHDKETPQ DSLVAPAQPP SQTFPPPSLP SKSVAMQQKP TAYVRPMDGQ
       310        320        330        340        350        360
DQAPSESPEL KPLPEDYRQQ TFEKTDLKVP AKAKLTKLKM PSQSVEQTYS NEVHCVEEIL
       370        380        390        400        410        420
KEMTHSWPPP LTAIHTPSTA EPSKFPFPTK DSQHVSSVTQ NQKQYDTSSK THSNSQQGTS
       430        440        450        460        470        480
SMLEDDLQLS DSEDSDSEQT PEKPPSSSAP PSAPQSLPEP VASAHSSSAE SESTSDSDSS
       490        500        510        520        530        540
SDSESESSSS DSEENEPLET PAPEPEPPTT NKWQLDNWLT KVSQPAAPPE GPRSTEPPRR
       550        560        570        580        590        600
HPESKGSSDS ATSQEHSESK DPPPKSSSKA PRAPPEAPHP GKRSCQKSPA QQEPPQRQTV
       610        620        630        640        650        660
GTKQPKKPVK ASARAGSRTS LQGEREPGLL PYGSRDQTSK DKPKVKTKGR PRAAASNEPK
       670        680        690        700        710        720
PAVPPSSEKK KHKSSLPAPS KALSGPEPAK DNVEDRTPEH FALVPLTESQ GPPHSGSGSR
       730        740        750        760        770        780
TSGCRQAVVV QEDSRKDRLP LPLRDTKLLS PLRDTPPPQS LMVKITLDLL SRIPQPPGKG
       790        800        810        820        830        840
SRQRKAEDKQ PPAGKKHSSE KRSSDSSSKL AKKRKGEAER DCDNKKIRLE KEIKSQSSSS
       850        860        870        880        890        900
SSSHKESSKT KPSRPSSQSS KKEMLPPPPV SSSSQKPAKP ALKRSRREAD TCGQDPPKSA
       910        920        930        940        950        960
SSTKSNHKDS SIPKQRRVEG KGSRSSSEHK GSSGDTANPF PVPSLPNGNS KPGKPQVKFD
       970        980        990       1000       1010       1020
KQQADLHMRE AKKMKQKAEL MTDRVGKAFK YLEAVLSFIE CGIATESESQ SSKSAYSVYS
      1030       1040       1050       1060       1070       1080
ETVDLIKFIM SLKSFSDATA PTQEKIFAVL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH
      1090       1100       1110       1120       1130       1140
FESSSKVAQA PSPCIASTGT PSPLSPMPSP ASSVGSQSSA GSVGSSGVAA TISTPVTIQN
      1150       1160       1170       1180       1190       1200
MTSSYVTITS HVLTAFDLWE QAEALTRKNK EFFARLSTNV CTLALNSSLV DLVHYTRQGF
      1210
QQLQELTKTP         10         20         30         40         50         60
MAAQSSLYND DRNLLRIREK ERRNQEAHQE KEAFPEKIPL FGEPYKTAKG DELSSRIQNM
        70         80         90        100        110        120
LGNYEEVKEF LSTKSHTHRL DASENRLGKP KYPLIPDKGS SIPSSSFHTS VHHQSIHTPA
       130        140        150        160        170        180
SGPLSVGNIS HNPKMAQPRT EPMPSLHAKS CGPPDSQHLT QDRLGQEGFG SSHHKKGDRR
       190        200        210        220        230        240
ADGDHCASVT DSAPERELSP LISLPSPVPP LSPIHSNQQT LPRTQGSSKV HGSSNNSKGY
       250        260        270        280        290        300
CPAKSPKDLA VKVHDKETPQ DSLVAPAQPP SQTFPPPSLP SKSVAMQQKP TAYVRPMDGQ
       310        320        330        340        350        360
DQAPSESPEL KPLPEDYRQQ TFEKTDLKVP AKAKLTKLKM PSQSVEQTYS NEVHCVEEIL
       370        380        390        400        410        420
KEMTHSWPPP LTAIHTPSTA EPSKFPFPTK DSQHVSSVTQ NQKQYDTSSK THSNSQQGTS
       430        440        450        460        470        480
SMLEDDLQLS DSEDSDSEQT PEKPPSSSAP PSAPQSLPEP VASAHSSSAE SESTSDSDSS
       490        500        510        520        530        540
SDSESESSSS DSEENEPLET PAPEPEPPTT NKWQLDNWLT KVSQPAAPPE GPRSTEPPRR
       550        560        570        580        590        600
HPESKGSSDS ATSQEHSESK DPPPKSSSKA PRAPPEAPHP GKRSCQKSPA QQEPPQRQTV
       610        620        630        640        650        660
GTKQPKKPVK ASARAGSRTS LQGEREPGLL PYGSRDQTSK DKPKVKTKGR PRAAASNEPK
       670        680        690        700        710        720
PAVPPSSEKK KHKSSLPAPS KALSGPEPAK DNVEDRTPEH FALVPLTESQ GPPHSGSGSR
       730        740        750        760        770        780
TSGCRQAVVV QEDSRKDRLP LPLRDTKLLS PLRDTPPPQS LMVKITLDLL SRIPQPPGKG
       790        800        810        820        830        840
SRQRKAEDKQ PPAGKKHSSE KRSSDSSSKL AKKRKGEAER DCDNKKIRLE KEIKSQSSSS
       850        860        870        880        890        900
SSSHKESSKT KPSRPSSQSS KKEMLPPPPV SSSSQKPAKP ALKRSRREAD TCGQDPPKSA
       910        920        930        940        950        960
SSTKSNHKDS SIPKQRRVEG KGSRSSSEHK GSSGDTANPF PVPSLPNGNS KPGKPQVKFD
       970        980        990       1000       1010       1020
KQQADLHMRE AKKMKQKAEL MTDRVGKAFK YLEAVLSFIE CGIATESESQ SSKSAYSVYS
      1030       1040       1050       1060       1070       1080
ETVDLIKFIM SLKSFSDATA PTQEKIFAVL CMRCQSILNM AMFRCKKDIA IKYSRTLNKH
      1090       1100       1110       1120       1130       1140
FESSSKVAQA PSPCIASTGT PSPLSPMPSP ASSVGSQSSA GSVGSSGVAA TISTPVTIQN
      1150       1160       1170       1180       1190       1200
MTSSYVTITS HVLTAFDLWE QAEALTRKNK EFFARLSTNV CTLALNSSLV DLVHYTRQGF
      1210
QQLQELTKTP

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51825-1-unknown	MAAQSS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51825-1-unknown	MAAQSS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66467
P51825-41-unknown	FGEPYK...	41	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14191
P51825-41-unknown	FGEPYK...	41	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138418
P51825-41-unknown	FGEPYK...	41	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139003
P51825-373-unknown	AIHTPS...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175830
P51825-373-unknown	AIHTPS...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175831
P51825-373-	AIHTPS...	373		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P51825-1090-unknown	APSPCI...	1090	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7533

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKIPLF	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14191
...EKIPLF	40	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121459
...EKIPLF	40	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122072
...SKVAQA	1089	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7533
...LTKTP	1210	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTKTP	1210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62085
...LTKTP	1210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62084

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	40	IPLF.\|.FGEP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	1089	VAQA.\|.APSP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

TopFIND

P51825: AF4/FMR2 family member 1

General Information

5

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates