P52655: Transcription initiation factor IIA subunit 1

General Information

Protein names	- Transcription initiation factor IIA subunit 1 - General transcription factor IIA subunit 1 - TFIIAL - Transcription initiation factor TFIIA 42 kDa subunit - TFIIA-42 - Transcription initiation factor IIA alpha chain - TFIIA p35 subunit - Transcription initiation factor IIA beta chain - TFIIA p19 subunit
Gene names	GTF2A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52655

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH
        70         80         90        100        110        120
SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV
       130        140        150        160        170        180
PDSKLIQHMN ASNMSAAATA ATLALPAGVT PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ
       190        200        210        220        230        240
SVVLQQQVIP QMQPGGVQAP VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV
       250        260        270        280        290        300
AAPTPAQAQI TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE
       310        320        330        340        350        360
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK FHLKDGIMNL
       370
NGRDYIFSKA IGDAEW

Isoforms

- Isoform 37 kDa of Transcription initiation factor IIA subunit 1

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52655-2-unknown	MANSAN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52655-2-Acetylation	ANSANT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52655-2-Acetylation	ANSANT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P52655-2-Acetylation	ANSANT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P52655-4-	SANTNT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52655-4-	SANTNT...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52655-40-unknown	MELKTL...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91924
P52655-275-unknown	GTGDTS...	275		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52655-275-unknown	GTGDTS...	275		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31669
P52655-275-unknown	GTGDTS...	275		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116108

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VLQVDG	274	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VLQVDG	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31669
...VLQVDG	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92184
...GDAEW	376	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GDAEW	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87542

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TASP1_HUMAN	274	QVDG.\|.GTGD	inferred from experiment	unknown	MEROPS	Stunnenberg HG	Zhou H et al.:Uncleaved TFIIA is a substrate ... (T02.004)	16537915,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)