P52701: DNA mismatch repair protein Msh6 {ECO:0000250|UniProtKB:P54276}

General Information

Protein names	- DNA mismatch repair protein Msh6 {ECO:0000250\|UniProtKB:P54276} - hMSH6 {ECO:0000303\|PubMed:8942985} - G/T mismatch-binding protein {ECO:0000303\|PubMed:7604265} - GTBP {ECO:0000303\|PubMed:9455487} - GTMBP {ECO:0000250\|UniProtKB:P54276} - MutS protein homolog 6 {ECO:0000312\|HGNC:HGNC:7329} - MutS-alpha 160 kDa subunit - p160 {ECO:0000303\|PubMed:7604264}
Gene names	MSH6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52701

10 N-termini

9 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform GTBP-alt of DNA mismatch repair protein Msh6 - Isoform 3 of DNA mismatch repair protein Msh6 - Isoform 4 of DNA mismatch repair protein Msh6

Sequence View

        10         20         30         40         50         60
MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW SEAGPGPRPL
        70         80         90        100        110        120
ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM EGYPWWPCLV YNHPFDGTFI
       130        140        150        160        170        180
REKGKSVRVH VQFFDDSPTR GWVSKRLLKP YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD
       190        200        210        220        230        240
EALNKDKIKR LELAVCDEPS EPEEEEEMEV GTTYVTDKSE EDNEIESEEE VQPKTQGSRR
       250        260        270        280        290        300
SSRQIKKRRV ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR
       310        320        330        340        350        360
KRMVTGNGSL KRKSSRKETP SATKQATSIS SETKNTLRAF SAPQNSESQA HVSGGGDDSS
       370        380        390        400        410        420
RPTVWYHETL EWLKEEKRRD EHRRRPDHPD FDASTLYVPE DFLNSCTPGM RKWWQIKSQN
       430        440        450        460        470        480
FDLVICYKVG KFYELYHMDA LIGVSELGLV FMKGNWAHSG FPEIAFGRYS DSLVQKGYKV
       490        500        510        520        530        540
ARVEQTETPE MMEARCRKMA HISKYDRVVR REICRIITKG TQTYSVLEGD PSENYSKYLL
       550        560        570        580        590        600
SLKEKEEDSS GHTRAYGVCF VDTSLGKFFI GQFSDDRHCS RFRTLVAHYP PVQVLFEKGN
       610        620        630        640        650        660
LSKETKTILK SSLSCSLQEG LIPGSQFWDA SKTLRTLLEE EYFREKLSDG IGVMLPQVLK
       670        680        690        700        710        720
GMTSESDSIG LTPGEKSELA LSALGGCVFY LKKCLIDQEL LSMANFEEYI PLDSDTVSTT
       730        740        750        760        770        780
RSGAIFTKAY QRMVLDAVTL NNLEIFLNGT NGSTEGTLLE RVDTCHTPFG KRLLKQWLCA
       790        800        810        820        830        840
PLCNHYAIND RLDAIEDLMV VPDKISEVVE LLKKLPDLER LLSKIHNVGS PLKSQNHPDS
       850        860        870        880        890        900
RAIMYEETTY SKKKIIDFLS ALEGFKVMCK IIGIMEEVAD GFKSKILKQV ISLQTKNPEG
       910        920        930        940        950        960
RFPDLTVELN RWDTAFDHEK ARKTGLITPK AGFDSDYDQA LADIRENEQS LLEYLEKQRN
       970        980        990       1000       1010       1020
RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK KGCKRYWTKT IEKKLANLIN
      1030       1040       1050       1060       1070       1080
AEERRDVSLK DCMRRLFYNF DKNYKDWQSA VECIAVLDVL LCLANYSRGG DGPMCRPVIL
      1090       1100       1110       1120       1130       1140
LPEDTPPFLE LKGSRHPCIT KTFFGDDFIP NDILIGCEEE EQENGKAYCV LVTGPNMGGK
      1150       1160       1170       1180       1190       1200
STLMRQAGLL AVMAQMGCYV PAEVCRLTPI DRVFTRLGAS DRIMSGESTF FVELSETASI
      1210       1220       1230       1240       1250       1260
LMHATAHSLV LVDELGRGTA TFDGTAIANA VVKELAETIK CRTLFSTHYH SLVEDYSQNV
      1270       1280       1290       1300       1310       1320
AVRLGHMACM VENECEDPSQ ETITFLYKFI KGACPKSYGF NAARLANLPE EVIQKGHRKA
      1330       1340       1350       1360
REFEKMNQSL RLFREVCLAS ERSTVDAEAV HKLLTLIKEL         10         20         30         40         50         60
MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW SEAGPGPRPL
        70         80         90        100        110        120
ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM EGYPWWPCLV YNHPFDGTFI
       130        140        150        160        170        180
REKGKSVRVH VQFFDDSPTR GWVSKRLLKP YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD
       190        200        210        220        230        240
EALNKDKIKR LELAVCDEPS EPEEEEEMEV GTTYVTDKSE EDNEIESEEE VQPKTQGSRR
       250        260        270        280        290        300
SSRQIKKRRV ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR
       310        320        330        340        350        360
KRMVTGNGSL KRKSSRKETP SATKQATSIS SETKNTLRAF SAPQNSESQA HVSGGGDDSS
       370        380        390        400        410        420
RPTVWYHETL EWLKEEKRRD EHRRRPDHPD FDASTLYVPE DFLNSCTPGM RKWWQIKSQN
       430        440        450        460        470        480
FDLVICYKVG KFYELYHMDA LIGVSELGLV FMKGNWAHSG FPEIAFGRYS DSLVQKGYKV
       490        500        510        520        530        540
ARVEQTETPE MMEARCRKMA HISKYDRVVR REICRIITKG TQTYSVLEGD PSENYSKYLL
       550        560        570        580        590        600
SLKEKEEDSS GHTRAYGVCF VDTSLGKFFI GQFSDDRHCS RFRTLVAHYP PVQVLFEKGN
       610        620        630        640        650        660
LSKETKTILK SSLSCSLQEG LIPGSQFWDA SKTLRTLLEE EYFREKLSDG IGVMLPQVLK
       670        680        690        700        710        720
GMTSESDSIG LTPGEKSELA LSALGGCVFY LKKCLIDQEL LSMANFEEYI PLDSDTVSTT
       730        740        750        760        770        780
RSGAIFTKAY QRMVLDAVTL NNLEIFLNGT NGSTEGTLLE RVDTCHTPFG KRLLKQWLCA
       790        800        810        820        830        840
PLCNHYAIND RLDAIEDLMV VPDKISEVVE LLKKLPDLER LLSKIHNVGS PLKSQNHPDS
       850        860        870        880        890        900
RAIMYEETTY SKKKIIDFLS ALEGFKVMCK IIGIMEEVAD GFKSKILKQV ISLQTKNPEG
       910        920        930        940        950        960
RFPDLTVELN RWDTAFDHEK ARKTGLITPK AGFDSDYDQA LADIRENEQS LLEYLEKQRN
       970        980        990       1000       1010       1020
RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK KGCKRYWTKT IEKKLANLIN
      1030       1040       1050       1060       1070       1080
AEERRDVSLK DCMRRLFYNF DKNYKDWQSA VECIAVLDVL LCLANYSRGG DGPMCRPVIL
      1090       1100       1110       1120       1130       1140
LPEDTPPFLE LKGSRHPCIT KTFFGDDFIP NDILIGCEEE EQENGKAYCV LVTGPNMGGK
      1150       1160       1170       1180       1190       1200
STLMRQAGLL AVMAQMGCYV PAEVCRLTPI DRVFTRLGAS DRIMSGESTF FVELSETASI
      1210       1220       1230       1240       1250       1260
LMHATAHSLV LVDELGRGTA TFDGTAIANA VVKELAETIK CRTLFSTHYH SLVEDYSQNV
      1270       1280       1290       1300       1310       1320
AVRLGHMACM VENECEDPSQ ETITFLYKFI KGACPKSYGF NAARLANLPE EVIQKGHRKA
      1330       1340       1350       1360
REFEKMNQSL RLFREVCLAS ERSTVDAEAV HKLLTLIKEL         10         20         30         40         50         60
MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW SEAGPGPRPL
        70         80         90        100        110        120
ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM EGYPWWPCLV YNHPFDGTFI
       130        140        150        160        170        180
REKGKSVRVH VQFFDDSPTR GWVSKRLLKP YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD
       190        200        210        220        230        240
EALNKDKIKR LELAVCDEPS EPEEEEEMEV GTTYVTDKSE EDNEIESEEE VQPKTQGSRR
       250        260        270        280        290        300
SSRQIKKRRV ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR
       310        320        330        340        350        360
KRMVTGNGSL KRKSSRKETP SATKQATSIS SETKNTLRAF SAPQNSESQA HVSGGGDDSS
       370        380        390        400        410        420
RPTVWYHETL EWLKEEKRRD EHRRRPDHPD FDASTLYVPE DFLNSCTPGM RKWWQIKSQN
       430        440        450        460        470        480
FDLVICYKVG KFYELYHMDA LIGVSELGLV FMKGNWAHSG FPEIAFGRYS DSLVQKGYKV
       490        500        510        520        530        540
ARVEQTETPE MMEARCRKMA HISKYDRVVR REICRIITKG TQTYSVLEGD PSENYSKYLL
       550        560        570        580        590        600
SLKEKEEDSS GHTRAYGVCF VDTSLGKFFI GQFSDDRHCS RFRTLVAHYP PVQVLFEKGN
       610        620        630        640        650        660
LSKETKTILK SSLSCSLQEG LIPGSQFWDA SKTLRTLLEE EYFREKLSDG IGVMLPQVLK
       670        680        690        700        710        720
GMTSESDSIG LTPGEKSELA LSALGGCVFY LKKCLIDQEL LSMANFEEYI PLDSDTVSTT
       730        740        750        760        770        780
RSGAIFTKAY QRMVLDAVTL NNLEIFLNGT NGSTEGTLLE RVDTCHTPFG KRLLKQWLCA
       790        800        810        820        830        840
PLCNHYAIND RLDAIEDLMV VPDKISEVVE LLKKLPDLER LLSKIHNVGS PLKSQNHPDS
       850        860        870        880        890        900
RAIMYEETTY SKKKIIDFLS ALEGFKVMCK IIGIMEEVAD GFKSKILKQV ISLQTKNPEG
       910        920        930        940        950        960
RFPDLTVELN RWDTAFDHEK ARKTGLITPK AGFDSDYDQA LADIRENEQS LLEYLEKQRN
       970        980        990       1000       1010       1020
RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK KGCKRYWTKT IEKKLANLIN
      1030       1040       1050       1060       1070       1080
AEERRDVSLK DCMRRLFYNF DKNYKDWQSA VECIAVLDVL LCLANYSRGG DGPMCRPVIL
      1090       1100       1110       1120       1130       1140
LPEDTPPFLE LKGSRHPCIT KTFFGDDFIP NDILIGCEEE EQENGKAYCV LVTGPNMGGK
      1150       1160       1170       1180       1190       1200
STLMRQAGLL AVMAQMGCYV PAEVCRLTPI DRVFTRLGAS DRIMSGESTF FVELSETASI
      1210       1220       1230       1240       1250       1260
LMHATAHSLV LVDELGRGTA TFDGTAIANA VVKELAETIK CRTLFSTHYH SLVEDYSQNV
      1270       1280       1290       1300       1310       1320
AVRLGHMACM VENECEDPSQ ETITFLYKFI KGACPKSYGF NAARLANLPE EVIQKGHRKA
      1330       1340       1350       1360
REFEKMNQSL RLFREVCLAS ERSTVDAEAV HKLLTLIKEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 9 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52701-1-unknown	MSRQST...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52701-1-unknown	MSRQST...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81609
P52701-1-unknown	MSRQST...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81610
P52701-48-unknown	AAWSEA...	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11658
P52701-48-unknown	AAWSEA...	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139014
P52701-48-unknown	AAWSEA...	48	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139015
P52701-100-unknown	MEGYPW...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475605
P52701-100-unknown	MEGYPW...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397484
P52701-100-unknown	MEGYPW...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390382
P52701-100-unknown	MEGYPW...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406248
P52701-100-unknown	MEGYPW...	100	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196947
P52701-303-unknown	MVTGNG...	303	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438580
P52701-303-unknown	MVTGNG...	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198854
P52701-303-unknown	MVTGNG...	303	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198855
P52701-328-unknown	SISSET...	328	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14195
P52701-328-unknown	SISSET...	328	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146518
P52701-328-unknown	SISSET...	328	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150484
P52701-541-unknown	SLKEKE...	541	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14198
P52701-541-unknown	SLKEKE...	541	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152173
P52701-541-unknown	SLKEKE...	541	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153885
P52701-541-	SLKEKE...	541		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52701-842-unknown	AIMYEE...	842	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178253
P52701-842-unknown	AIMYEE...	842	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178254
P52701-842-	AIMYEE...	842		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52701-935-unknown	SDYDQA...	935	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11661
P52701-935-unknown	SDYDQA...	935	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156508
P52701-935-unknown	SDYDQA...	935	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157024

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SPGGDA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11658
...SPGGDA	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122083
...SPGGDA	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122084
...RLLKPY	150	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475605
...RLLKPY	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154968
...CDEPSE	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390382
...CDEPSE	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155609
...VGTTYV	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397484
...VGTTYV	214	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155757
...KKRRVI	250	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406248
...TKQATS	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14195
...TKQATS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129826
...TKQATS	327	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133879
...SKYLLS	540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14198
...SKYLLS	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135583
...SKYLLS	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137307
...KAGFDS	934	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11661
...KAGFDS	934	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139992
...KAGFDS	934	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140516
...LIKEL	1360	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LIKEL	1360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77228

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	47	GGDA.\|.AAWS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	327	QATS.\|.SISS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	540	YLLS.\|.SLKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	934	GFDS.\|.SDYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)