P55084: Trifunctional enzyme subunit beta, mitochondrial

General Information

Protein names	- Trifunctional enzyme subunit beta, mitochondrial - TP-beta - 3-ketoacyl-CoA thiolase - 2.3.1.155 {ECO:0000269\|PubMed:7958339, ECO:0000269\|PubMed:8135828, ECO:0000269\|PubMed:8163672, ECO:0000269\|PubMed:8651282} - 2.3.1.16 {ECO:0000269\|PubMed:1550553, ECO:0000269\|PubMed:7958339, ECO:0000269\|PubMed:8135828, ECO:0000269\|PubMed:8163672, ECO:0000269\|PubMed:8651282} - Acetyl-CoA acyltransferase - Beta-ketothiolase
Gene names	HADHB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55084

4 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV
        70         80         90        100        110        120
RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA
       130        140        150        160        170        180
LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR
       190        200        210        220        230        240
KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE
       250        260        270        280        290        300
QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY
       310        320        330        340        350        360
GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP
       370        380        390        400        410        420
KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW
       430        440        450        460        470
GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK

Isoforms

- Isoform 2 of Trifunctional enzyme subunit beta, mitochondrial

Sequence View

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Evidence Codes:

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Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55084-34-unknown	AAPAVQ...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55084-34-unknown	AAPAVQ...	34		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P55084-34-unknown	AAPAVQ...	34		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P55084-34-	AAPAVQ...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P55084-218-	STSETM...	218		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P55084-218-unknown	STSETM...	218	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173901

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARAALT	84	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413103
...ARAALT	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110898
...MTTGVG	149	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415300
...MTTGVG	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110894
...VPIRHS	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404633
...VPIRHS	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110896
...EAYPK	474	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAYPK	474	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69201

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)