P57740: Nuclear pore complex protein Nup107

General Information

Protein names	- Nuclear pore complex protein Nup107 - 107 kDa nucleoporin - Nucleoporin Nup107
Gene names	NUP107
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P57740

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear pore complex protein Nup107 - Isoform 3 of Nuclear pore complex protein Nup107

Sequence View

        10         20         30         40         50         60
MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR
        70         80         90        100        110        120
QPFTPTSRSL LRQPDISCIL GTGGKSPRLT QSSGFFGNLS MVTNLDDSNW AAAFSSQRSG
       130        140        150        160        170        180
LFTNTEPHSI TEDVTISAVM LREDDPGEAA SMSMFSDFLQ SFLKHSSSTV FDLVEEYENI
       190        200        210        220        230        240
CGSQVNILSK IVSRATPGLQ KFSKTASMLW LLQQEMVTWR LLASLYRDRI QSALEEESVF
       250        260        270        280        290        300
AVTAVNASEK TVVEALFQRD SLVRQSQLVV DWLESIAKDE IGEFSDNIEF YAKSVYWENT
       310        320        330        340        350        360
LHTLKQRQLT SYVGSVRPLV TELDPDAPIR QKMPLDDLDR EDEVRLLKYL FTLIRAGMTE
       370        380        390        400        410        420
EAQRLCKRCG QAWRAATLEG WKLYHDPNVN GGTELEPVEG NPYRRIWKIS CWRMAEDELF
       430        440        450        460        470        480
NRYERAIYAA LSGNLKQLLP VCDTWEDTVW AYFRVMVDSL VEQEIQTSVA TLDETEELPR
       490        500        510        520        530        540
EYLGANWTLE KVFEELQATD KKRVLEENQE HYHIVQKFLI LGDIDGLMDE FSKWLSKSRN
       550        560        570        580        590        600
NLPGHLLRFM THLILFFRTL GLQTKEEVSI EVLKTYIQLL IREKHTNLIA FYTCHLPQDL
       610        620        630        640        650        660
AVAQYALFLE SVTEFEQRHH CLELAKEADL DVATITKTVV ENIRKKDNGE FSHHDLAPAL
       670        680        690        700        710        720
DTGTTEEDRL KIDVIDWLVF DPAQRAEALK QGNAIMRKFL ASKKHEAAKE VFVKIPQDSI
       730        740        750        760        770        780
AEIYNQCEEQ GMESPLPAED DNAIREHLCI RAYLEAHETF NEWFKHMNSV PQKPALIPQP
       790        800        810        820        830        840
TFTEKVAHEH KEKKYEMDFG IWKGHLDALT ADVKEKMYNV LLFVDGGWMV DVREDAKEDH
       850        860        870        880        890        900
ERTHQMVLLR KLCLPMLCFL LHTILHSTGQ YQECLQLADM VSSERHKLYL VFSKEELRKL
       910        920
LQKLRESSLM LLDQGLDPLG YEIQL         10         20         30         40         50         60
MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR
        70         80         90        100        110        120
QPFTPTSRSL LRQPDISCIL GTGGKSPRLT QSSGFFGNLS MVTNLDDSNW AAAFSSQRSG
       130        140        150        160        170        180
LFTNTEPHSI TEDVTISAVM LREDDPGEAA SMSMFSDFLQ SFLKHSSSTV FDLVEEYENI
       190        200        210        220        230        240
CGSQVNILSK IVSRATPGLQ KFSKTASMLW LLQQEMVTWR LLASLYRDRI QSALEEESVF
       250        260        270        280        290        300
AVTAVNASEK TVVEALFQRD SLVRQSQLVV DWLESIAKDE IGEFSDNIEF YAKSVYWENT
       310        320        330        340        350        360
LHTLKQRQLT SYVGSVRPLV TELDPDAPIR QKMPLDDLDR EDEVRLLKYL FTLIRAGMTE
       370        380        390        400        410        420
EAQRLCKRCG QAWRAATLEG WKLYHDPNVN GGTELEPVEG NPYRRIWKIS CWRMAEDELF
       430        440        450        460        470        480
NRYERAIYAA LSGNLKQLLP VCDTWEDTVW AYFRVMVDSL VEQEIQTSVA TLDETEELPR
       490        500        510        520        530        540
EYLGANWTLE KVFEELQATD KKRVLEENQE HYHIVQKFLI LGDIDGLMDE FSKWLSKSRN
       550        560        570        580        590        600
NLPGHLLRFM THLILFFRTL GLQTKEEVSI EVLKTYIQLL IREKHTNLIA FYTCHLPQDL
       610        620        630        640        650        660
AVAQYALFLE SVTEFEQRHH CLELAKEADL DVATITKTVV ENIRKKDNGE FSHHDLAPAL
       670        680        690        700        710        720
DTGTTEEDRL KIDVIDWLVF DPAQRAEALK QGNAIMRKFL ASKKHEAAKE VFVKIPQDSI
       730        740        750        760        770        780
AEIYNQCEEQ GMESPLPAED DNAIREHLCI RAYLEAHETF NEWFKHMNSV PQKPALIPQP
       790        800        810        820        830        840
TFTEKVAHEH KEKKYEMDFG IWKGHLDALT ADVKEKMYNV LLFVDGGWMV DVREDAKEDH
       850        860        870        880        890        900
ERTHQMVLLR KLCLPMLCFL LHTILHSTGQ YQECLQLADM VSSERHKLYL VFSKEELRKL
       910        920
LQKLRESSLM LLDQGLDPLG YEIQL

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P57740-1-Acetylation	MDRSGF...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P57740-4-unknown	SGFGEI...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10110
P57740-101-unknown	MVTNLD...	101		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440116
P57740-101-unknown	MVTNLD...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130883
P57740-101-	MVTNLD...	101			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P57740-152-unknown	MSMFSD...	152		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83476
P57740-152-unknown	MSMFSD...	152		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000368185
P57740-152-unknown	MSMFSD...	152		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97027
P57740-694-unknown	AIMRKF...	694		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14221
P57740-694-unknown	AIMRKF...	694		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152840
P57740-694-unknown	AIMRKF...	694		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155474

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...CGSQVN	185	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440116
...CGSQVN	185	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt110685
...CGSQVN	185	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt110684
...LKQGNA	693	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14221
...LKQGNA	693	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136265
...LKQGNA	693	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138909
...YEIQL	925		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YEIQL	925	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YEIQL	925	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79094
...YEIQL	925	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79093
...YEIQL	925		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	3	MDRS.\|.SGFG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	693	QGNA.\|.AIMR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)