P57764: Gasdermin-D

General Information

Protein names	- Gasdermin-D - Gasdermin domain-containing protein 1 - Gasdermin-D, N-terminal {ECO:0000250\|UniProtKB:Q9D8T2} - GSDMD-NT - Gasdermin-D, C-terminal {ECO:0000250\|UniProtKB:Q9D8T2} - GSDMD-CT
Gene names	GSDMD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P57764

4 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGSAFERVVR RVVQELDHGG EFIPVTSLQS STGFQPYCLV VRKPSSSWFW KPRYKCVNLS
        70         80         90        100        110        120
IKDILEPDAA EPDVQRGRSF HFYDAMDGQI QGSVELAAPG QAKIAGGAAV SDSSSTSMNV
       130        140        150        160        170        180
YSLSVDPNTW QTLLHERHLR QPEHKVLQQL RSRGDNVYVV TEVLQTQKEV EVTRTHKREG
       190        200        210        220        230        240
SGRFSLPGAT CLQGEGQGHL SQKKTVTIPS GSTLAFRVAQ LVIDSDLDVL LFPDKKQRTF
       250        260        270        280        290        300
QPPATGHKRS TSEGAWPQLP SGLSMMRCLH NFLTDGVPAE GAFTEDFQGL RAEVETISKE
       310        320        330        340        350        360
LELLDRELCQ LLLEGLEGVL RDQLALRALE EALEQGQSLG PVEPLDGPAG AVLECLVLSS
       370        380        390        400        410        420
GMLVPELAIP VVYLLGALTM LSETQHKLLA EALESQTLLG PLELVGSLLE QSAPWQERST
       430        440        450        460        470        480
MSLPPGLLGN SWGEGAPAWV LLDECGLELG EDTPHVCWEP QAQGRMCALY ASLALLSGLS

QEPH

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P57764-1-unknown	MGSAFE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P57764-88-	GQIQGS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P57764-88-	GQIQGS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P57764-88-	GQIQGS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P57764-88-	GQIQGS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P57764-88-	GQIQGS...	88		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P57764-276-unknown	GVPAEG...	276	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1251
P57764-276-unknown	GVPAEG...	276	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P57764-276-	GVPAEG...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P57764-276-	GVPAEG...	276		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P57764-276-	GVPAEG...	276		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P57764-276-	GVPAEG...	276		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSSSWF	48	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432351
...VSDSSS	114	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434452
...QLRSRG	153	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437065
...VTEVLQ	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434386
...PQLPSG	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436684
...NFLTDG	275	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1251
...NFLTDG	275	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SQEPH	484	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	275	LTDG.\|.GVPA	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)