P59998: Actin-related protein 2/3 complex subunit 4

General Information

Protein names	- Actin-related protein 2/3 complex subunit 4 - Arp2/3 complex 20 kDa subunit - p20-ARC
Gene names	ARPC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P59998

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Actin-related protein 2/3 complex subunit 4 - Isoform 3 of Actin-related protein 2/3 complex subunit 4 - Isoform 4 of Actin-related protein 2/3 complex subunit 4

Sequence View

        10         20         30         40         50         60
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
        70         80         90        100        110        120
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
       130        140        150        160
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF         10         20         30         40         50         60
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
        70         80         90        100        110        120
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
       130        140        150        160
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF         10         20         30         40         50         60
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
        70         80         90        100        110        120
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
       130        140        150        160
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P59998-2-unknown	MTATLR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P59998-2-unknown	MTATLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171522
P59998-2-unknown	MTATLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171521
P59998-1-unknown	MTATLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67548
P59998-2-	TATLRP...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P59998-2-Acetylation	TATLRP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P59998-2-Acetylation	TATLRP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P59998-2-Acetylation	TATLRP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110055
P59998-2-Acetylation	TATLRP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110054
P59998-91-unknown	MRFMMM...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67550
P59998-91-unknown	MRFMMM...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108238

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EFLKNF	167	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8230
...EFLKNF	167	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt124326
...EFLKNF	167	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129427
...FLKNF	168	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FLKNF	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt63168
...FLKNF	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt63167
...FLKNF	168		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FLKNF	168		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...FLKNF	168		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FLKNF	168		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CBPA4_HUMAN	167	LKNF.\|.F	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)