P60228: Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit E {ECO:0000255\|HAMAP-Rule:MF_03004} - eIF3e {ECO:0000255\|HAMAP-Rule:MF_03004} - Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255\|HAMAP-Rule:MF_03004} - Viral integration site protein INT-6 homolog - eIF-3 p48 {ECO:0000255\|HAMAP-Rule:MF_03004}
Gene names	EIF3E
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P60228

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN
        70         80         90        100        110        120
LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK
       130        140        150        160        170        180
HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ
       190        200        210        220        230        240
NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP
       250        260        270        280        290        300
QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY
       310        320        330        340        350        360
VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL
       370        380        390        400        410        420
NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM
       430        440
NIEKKLNQNS RSEAPNWATQ DSGFY

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P60228-2-unknown	MAEYDL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60228-2-Acetylation	AEYDLT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60228-2-Acetylation	AEYDLT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P60228-2-Acetylation	AEYDLT...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P60228-2-Acetylation	AEYDLT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P60228-11-unknown	AHFLDR...	11		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P60228-50-unknown	MVDFAM...	50		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430678
P60228-94-	MFEDPE...	94			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P60228-94-	MFEDPE...	94			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P60228-94-unknown	MFEDPE...	94		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428796

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KHGFRQ	124	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430678
...QCISIN	353	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430839
...WATQDS	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11738
...DSGFY	445	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	441	TQDS.\|.SGFY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)