P62191: 26S proteasome regulatory subunit 4

General Information

Protein names	- 26S proteasome regulatory subunit 4 - P26s4 - 26S proteasome AAA-ATPase subunit RPT2 - Proteasome 26S subunit ATPase 1
Gene names	PSMC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62191

7 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP LVTPHTQCRL
        70         80         90        100        110        120
KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD DLRGTPMSVG TLEEIIDDNH
       130        140        150        160        170        180
AIVSTSVGSE HYVSILSFVD KDLLEPGCSV LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP
       190        200        210        220        230        240
QETYADIGGL DNQIQEIKES VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA
       250        260        270        280        290        300
NQTSATFLRV VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG
       310        320        330        340        350        360
GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK IEFPLPDEKT
       370        380        390        400        410        420
KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT EAGLMALRER RMKVTNEDFK
       430        440
KSKENVLYKK QEGTPEGLYL

Isoforms

- Isoform 2 of 26S proteasome regulatory subunit 4

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62191-2-unknown	GQSQSG...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62191-2-unknown	GQSQSG...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62191-2-Myristoyl	GQSQSG...	2		other		CNRS/ISV	Large_scale_NTA_Human
P62191-74-unknown	MEEEFI...	74	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445147
P62191-164-unknown	MDDTDP...	164	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452049
P62191-238-	AVANQT...	238		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62191-336-unknown	TLDPAL...	336	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17780
P62191-338-unknown	DPALIR...	338	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17781

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TSATFL	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452049
...TNRIET	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17780
...RIETLD	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17781
...EGLYL	440	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	335	RIET.\|.TLDP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	337	ETLD.\|.DPAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)