P62495: Eukaryotic peptide chain release factor subunit 1

General Information

Protein names	- Eukaryotic peptide chain release factor subunit 1 - Eukaryotic release factor 1 - eRF1 - Protein Cl1 - TB3-1
Gene names	ETF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62495

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADDPSAADR NVEIWKIKKL IKSLEAARGN GTSMISLIIP PKDQISRVAK MLADEFGTAS
        70         80         90        100        110        120
NIKSRVNRLS VLGAITSVQQ RLKLYNKVPP NGLVVYCGTI VTEEGKEKKV NIDFEPFKPI
       130        140        150        160        170        180
NTSLYLCDNK FHTEALTALL SDDSKFGFIV IDGSGALFGT LQGNTREVLH KFTVDLPKKH
       190        200        210        220        230        240
GRGGQSALRF ARLRMEKRHN YVRKVAETAV QLFISGDKVN VAGLVLAGSA DFKTELSQSD
       250        260        270        280        290        300
MFDQRLQSKV LKLVDISYGG ENGFNQAIEL STEVLSNVKF IQEKKLIGRY FDEISQDTGK
       310        320        330        340        350        360
YCFGVEDTLK ALEMGAVEIL IVYENLDIMR YVLHCQGTEE EKILYLTPEQ EKDKSHFTDK
       370        380        390        400        410        420
ETGQEHELIE SMPLLEWFAN NYKKFGATLE IVTDKSQEGS QFVKGFGGIG GILRYRVDFQ
       430
GMEYQGGDDE FFDLDDY

Isoforms

- Isoform 2 of Eukaryotic peptide chain release factor subunit 1

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P62495-2-unknown	MADDPS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62495-2-Acetylation	ADDPSA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62495-2-Acetylation	ADDPSA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62495-34-unknown	MISLII...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421288
P62495-34-unknown	MISLII...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000461082
P62495-34-unknown	MISLII...	34		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425689
P62495-224-unknown	LVLAGS...	224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3886

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FIVIDG	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425689
...VNVAGL	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3886
...SQSDMF	241	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461082
...DLDDY	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	223	VAGL.\|.LVLA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)