TopFIND 4.0

P62877: E3 ubiquitin-protein ligase RBX1

General Information

Protein names	- E3 ubiquitin-protein ligase RBX1 - 2.3.2.27 {ECO:0000269\|PubMed:11027288} - 2.3.2.32 {ECO:0000269\|PubMed:11027288} - E3 ubiquitin-protein transferase RBX1 {ECO:0000305} - Protein ZYP - RING finger protein 75 - RING-box protein 1 - Rbx1 - Regulator of cullins 1 - ROC1 {ECO:0000303\|PubMed:10230407} - E3 ubiquitin-protein ligase RBX1, N-terminally processed - E3 ubiquitin-protein transferase RBX1, N-terminally processed {ECO:0000305}
Gene names	RBX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62877

4

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ
70 80 90 100
ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62877-1-Acetylation	MAAAMD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62877-2-Acetylation	AAAMDV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62877-2-Acetylation	AAAMDV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62877-2-Acetylation	AAAMDV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62877-2-Acetylation	AAAMDV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62877-2-Acetylation	AAAMDV...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62877-6-unknown	DVDTPS...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14276
P62877-9-unknown	TPSGTN...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1974

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MAAAMD	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14276
	...AMDVDT	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1974
	...QKYGH	108	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...QKYGH	108		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
	...QKYGH	108		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	AAMD.\|.DVDT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	8	DVDT.\|.TPSG	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> RBX1_HUMAN @8

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)