P63244: Receptor of activated protein C kinase 1

General Information

Protein names	- Receptor of activated protein C kinase 1 - Cell proliferation-inducing gene 21 protein - Guanine nucleotide-binding protein subunit beta-2-like 1 - Guanine nucleotide-binding protein subunit beta-like protein 12.3 - Human lung cancer oncogene 7 protein - HLC-7 - Receptor for activated C kinase - Small ribosomal subunit protein RACK1 {ECO:0000303\|PubMed:24524803} - Receptor of activated protein C kinase 1, N-terminally processed - Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed
Gene names	GNB2L1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63244

8 N-termini

10 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
        70         80         90        100        110        120
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI
       130        140        150        160        170        180
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA
       190        200        210        220        230        240
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC
       250        260        270        280        290        300
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
       310
GYTDNLVRVW QVTIGTR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 10 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63244-1-Acetylation	MTEQMT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63244-1-Acetylation	MTEQMT...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63244-1-Acetylation	MTEQMT...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63244-1-Acetylation	MTEQMT...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63244-2-Acetylation	TEQMTL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63244-2-Acetylation	TEQMTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63244-2-Acetylation	TEQMTL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63244-13-	GHNGWV...	13			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P63244-20-unknown	QIATTP...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3901
P63244-42-unknown	MWKLTR...	42		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421416
P63244-79-unknown	LSGSWD...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3902
P63244-110-unknown	SVAFSS...	110		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14284
P63244-217-unknown	MLWDLN...	217		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426708

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NGWVTQ	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3901
...DGQFAL	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3902
...TKDVLS	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14284
...CVRFSP	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421356
...ANCKLK	184	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424237
...DGGDII	235	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421416
...YWLCAA	250	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422029
...LCAATG	252	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423569
...FAGYTD	303	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425008
...TIGTR	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	19	WVTQ.\|.QIAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	78	QFAL.\|.LSGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	109	DVLS.\|.SVAF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)