P63267: Actin, gamma-enteric smooth muscle

General Information

Protein names	- Actin, gamma-enteric smooth muscle - Alpha-actin-3 - Gamma-2-actin - Smooth muscle gamma-actin - Actin, gamma-enteric smooth muscle, intermediate form
Gene names	ACTG2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63267

12 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
        70         80         90        100        110        120
SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE EHPTLLTEAP LNPKANREKM
       130        140        150        160        170        180
TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THNVPIYEGY ALPHAIMRLD
       190        200        210        220        230        240
LAGRDLTDYL MKILTERGYS FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS
       250        260        270        280        290        300
YELPDGQVIT IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL
       310        320        330        340        350        360
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
       370
PEYDEAGPSI VHRKCF

Isoforms

- Isoform 2 of Actin, gamma-enteric smooth muscle

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P63267-1-unknown	MCEEET...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66232
P63267-2-unknown	CEEETT...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163313
P63267-2-unmodified	CEEETT...	2			other		CNRS/ISV	Large_scale_NTA_Human
P63267-3-unknown	EEETTA...	3		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63267-3-unknown	EEETTA...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111752
P63267-3-acetylation	EEETTA...	3	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63267-3-acetylation	EEETTA...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163311
P63267-3-acetylation	EEETTA...	3	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63267-3-acetylation	EEETTA...	3	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63267-19-unknown	KAGFAG...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15338
P63267-19-unknown	KAGFAG...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136809
P63267-20-unknown	AGFAGD...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10152
P63267-20-unknown	AGFAGD...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136872
P63267-49-unknown	GQKDSY...	49		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14288
P63267-49-unknown	GQKDSY...	49		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63267-49-unknown	GQKDSY...	49		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63267-53-unknown	SYVGDE...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1979
P63267-107-unknown	TEAPLN...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15340
P63267-107-unknown	TEAPLN...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140260
P63267-108-unknown	EAPLNP...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15342
P63267-108-unknown	EAPLNP...	108		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140331
P63267-218-unknown	CYVALD...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14289
P63267-218-unknown	CYVALD...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145713

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSGLCK	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15338
...SGLCKA	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10152
...VMVGMG	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14288
...MGQKDS	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1979
...HPTLLT	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15340
...HPTLLT	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123381
...PTLLTE	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15342
...PTLLTE	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123453
...IKEKLC	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14289
...IKEKLC	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129011
...HRKCF	376	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HRKCF	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61850

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	18	GLCK.\|.KAGF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	19	LCKA.\|.AGFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	48	VGMG.\|.GQKD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	52	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
HTRA2_HUMAN	106	TLLT.\|.TEAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	107	LLTE.\|.EAPL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	217	EKLC.\|.CYVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)