P78362: SRSF protein kinase 2

General Information

Protein names	- SRSF protein kinase 2 - 2.7.11.1 - SFRS protein kinase 2 - Serine/arginine-rich protein-specific kinase 2 - SR-protein-specific kinase 2 - SRSF protein kinase 2 N-terminal - SRSF protein kinase 2 C-terminal
Gene names	SRPK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78362

9 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPPPLPDP TPPEPEEEIL GSDDEEQEDP
        70         80         90        100        110        120
ADYCKGGYHP VKIGDLFNGR YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE
       130        140        150        160        170        180
TALDEIKLLK CVRESDPSDP NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS
       190        200        210        220        230        240
NYQGLPVRCV KSIIRQVLQG LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ
       250        260        270        280        290        300
KAGAPPPSGS AVSTAPQQKP IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK
       310        320        330        340        350        360
IIEENITSAA PSNDQDGEYC PEVKLKTTGL EEAAEAETAK DNGEAEDQEE KEDAEKENIE
       370        380        390        400        410        420
KDEDDVDQEL ANIDPTWIES PKTNGHIENG PFSLEQQLDD EDDDEEDCPN PEEYNLDEPN
       430        440        450        460        470        480
AESDYTYSSS YEQFNGELPN GRHKIPESQF PEFSTSLFSG SLEPVACGSV LSEGSPLTEQ
       490        500        510        520        530        540
EESSPSHDRS RTVSASSTGD LPKAKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH
       550        560        570        580        590        600
FTEDIQTRQY RSIEVLIGAG YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA
       610        620        630        640        650        660
HIIELLGSIP RHFALSGKYS REFFNRRGEL RHITKLKPWS LFDVLVEKYG WPHEDAAQFT
       670        680
DFLIPMLEMV PEKRASAGEC LRHPWLNS

Isoforms

- Isoform 2 of SRSF protein kinase 2

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78362-1-unknown	MSVNSE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78362-140-unknown	PNKDMV...	140	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78362-140-unknown	PNKDMV...	140	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115946
P78362-200-unknown	GLDYLH...	200	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7684
P78362-200-unknown	GLDYLH...	200	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146979
P78362-250-unknown	SAVSTA...	250		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P78362-250-unknown	SAVSTA...	250	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160311
P78362-250-	SAVSTA...	250		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P78362-250-	SAVSTA...	250		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P78362-254-unknown	TAPQQK...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7686
P78362-254-unknown	TAPQQK...	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148972
P78362-315-unknown	QDGEYC...	315	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11830
P78362-315-unknown	QDGEYC...	315	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150443
P78362-371-unknown	ANIDPT...	371	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165777
P78362-371-	ANIDPT...	371		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P78362-371-	ANIDPT...	371		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDPSDP	139	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SDPSDP	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91658
...RQVLQG	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7684
...RQVLQG	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130311
...GSAVST	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7686
...GSAVST	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132353
...APSNDQ	314	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11830
...APSNDQ	314	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133839
...PWLNS	688	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PWLNS	688	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86311

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	199	VLQG.\|.GLDY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	253	AVST.\|.TAPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	314	SNDQ.\|.QDGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)