P82970: High mobility group nucleosome-binding domain-containing protein 5

General Information

Protein names	- High mobility group nucleosome-binding domain-containing protein 5 - Nucleosome-binding protein 1
Gene names	HMGN5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P82970

11 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD MMEENIDTSA
        70         80         90        100        110        120
QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV KEENIEDATE KGGEKKEAVA
       130        140        150        160        170        180
AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD EKGEEDGKED KNGNEKGEDA KEKEDGKKGE
       190        200        210        220        230        240
DGKGNGEDGK EKGEDEKEEE DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE
       250        260        270        280
DEGGNEEEAG KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P82970-1-unknown	MPKRKA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P82970-24-	SAMLVP...	24		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P82970-24-unknown	SAMLVP...	24		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P82970-25-	AMLVPV...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P82970-25-	AMLVPV...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P82970-25-	AMLVPV...	25		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P82970-26-	MLVPVT...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P82970-26-unknown	MLVPVT...	26		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P82970-27-	LVPVTP...	27		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P82970-27-unknown	LVPVTP...	27		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P82970-28-unknown	VPVTPE...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17818
P82970-58-	TSAQAV...	58		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P82970-58-	TSAQAV...	58		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P82970-70-	AVVEED...	70		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P82970-70-	AVVEED...	70		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LSAMLV	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17818
...AKITEA	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404810
...VEVKEE	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413402
...AGKEDK	148	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399626
...GEDAKE	171	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000362347
...KGDKKE	221	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408060
...PQSIV	282	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	27	AMLV.\|.VPVT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)