P97821: Dipeptidyl peptidase 1

General Information

Protein names	- Dipeptidyl peptidase 1 - 3.4.14.1 - Cathepsin C - Cathepsin J - Dipeptidyl peptidase I - DPP-I - DPPI - Dipeptidyl transferase - Dipeptidyl peptidase 1 exclusion domain chain - Dipeptidyl peptidase I exclusion domain chain - Dipeptidyl peptidase 1 heavy chain - Dipeptidyl peptidase I heavy chain - Dipeptidyl peptidase 1 light chain - Dipeptidyl peptidase I light chain
Gene names	Ctsc
Organism	Mus musculus
Protease Family	C01.070
Protease ID	C01.070
Chromosome location
UniProt ID	P97821

4 N-termini

4 C-termini

0 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS DINCSVMEAT
        70         80         90        100        110        120
EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK WFAFFKYEVR GHTAISYCHE
       130        140        150        160        170        180
TMTGWVHDVL GRNWACFVGK KVESHIEKVN MNAAHLGGLQ ERYSERLYTH NHNFVKAINT
       190        200        210        220        230        240
VQKSWTATAY KEYEKMSLRD LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ
       250        260        270        280        290        300
GVNYVSPVRN QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG
       310        320        330        340        350        360
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF YGGCNEALMK
       370        380        390        400        410        420
LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE LTNHAVLLVG YGRDPVTGIE
       430        440        450        460
YWIIKNSWGS NWGESGYFRI RRGTDECAIE SIAVAAIPIP KL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P97821-25-unknown	DTPANC...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P97821-228-unmodified	LNLPES...	228		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P97821-231-unknown	PESWDW...	231	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P97821-231-unknown	PESWDW...	231	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P97821-394-unknown	DPFNPF...	394	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGRNWA	134	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QESCGS	255	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119503
...HTGLSD	393	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PIPKL	462	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	20	AGEI.\|.IIGG	inferred from experiment	unknown	MEROPS	Ley TJ	Pham CT et al.:Dipeptidyl peptidase I is requi... (C01.070)	10411926,
MCPT2_MOUSE	20	AEEI.\|.IIGG	inferred from experiment	unknown	MEROPS	Thiele DL	McGuire MJ et al.:Generation of active myeloid an... (C01.070)	8428921,
MCPT4_MOUSE	20	AEEI.\|.IIGG	inferred from experiment	unknown	MEROPS	Thiele DL	McGuire MJ et al.:Generation of active myeloid an... (C01.070)	8428921,
GRAA_MOUSE	28	CERI.\|.IIGG	inferred from experiment	unknown	MEROPS	Ley TJ	Pham CT et al.:Dipeptidyl peptidase I is requi... (C01.070)	10411926,