P98170: E3 ubiquitin-protein ligase XIAP

General Information

Protein names	- E3 ubiquitin-protein ligase XIAP - 2.3.2.27 - Baculoviral IAP repeat-containing protein 4 - IAP-like protein - ILP - hILP - Inhibitor of apoptosis protein 3 - IAP-3 - hIAP-3 - hIAP3 - RING-type E3 ubiquitin transferase XIAP - X-linked inhibitor of apoptosis protein - X-linked IAP
Gene names	XIAP
Organism	Homo sapiens
Protease Family
Protease ID	I32.004
Chromosome location
UniProt ID	P98170

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA GFLYTGEGDT
        70         80         90        100        110        120
VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN SATQSTNSGI QNGQYKVENY
       130        140        150        160        170        180
LGSRDHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT
       190        200        210        220        230        240
PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE
       250        260        270        280        290        300
SDAVSSDRNF PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC
       310        320        330        340        350        360
FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP
       370        380        390        400        410        420
SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD
       430        440        450        460        470        480
SMQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK
       490
CPMCYTVITF KQKIFMS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P98170-1-unknown	MTFNSF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P98170-243-	AVSSDR...	243		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P98170-243-	AVSSDR...	243		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P98170-243-	AVSSDR...	243		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P98170-243-unknown	AVSSDR...	243	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2884
P98170-243-unknown	AVSSDR...	243	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1988

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIYPRN	156	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400637
...RSESDA	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2884
...RSESDA	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1988
...KIFMS	497	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	242	ESDA.\|.AVSS	inferred from experiment	unknown	MEROPS	Reed JC	Deveraux QL et al.:Cleavage of human inhibitor of ... (C14.003)	10508158,
CASP3_HUMAN	242	ESDA.\|.AVSS	inferred from experiment	unknown	MEROPS	Reed JC	Deveraux QL et al.:Cleavage of human inhibitor of ... (C14.003)	10508158,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)