Q00536: Cyclin-dependent kinase 16

General Information

Protein names	- Cyclin-dependent kinase 16 - 2.7.11.22 - Cell division protein kinase 16 - PCTAIRE-motif protein kinase 1 - Serine/threonine-protein kinase PCTAIRE-1
Gene names	CDK16
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00536

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cyclin-dependent kinase 16 - Isoform 3 of Cyclin-dependent kinase 16

Sequence View

        10         20         30         40         50         60
MDRMKKIKRQ LSMTLRGGRG IDKTNGAPEQ IGLDESGGGG GSDPGEAPTR AAPGELRSAR
        70         80         90        100        110        120
GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL
       130        140        150        160        170        180
PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY
       190        200        210        220        230        240
KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF
       250        260        270        280        290        300
EYLDKDLKQY LDDCGNIINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL
       310        320        330        340        350        360
KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP
       370        380        390        400        410        420
LFPGSTVEEQ LHFIFRILGT PTEETWPGIL SNEEFKTYNY PKYRAEALLS HAPRLDSDGA
       430        440        450        460        470        480
DLLTKLLQFE GRNRISAEDA MKHPFFLSLG ERIHKLPDTT SIFALKEIQL QKEASLRSSS
       490
MPDSGRPAFR VVDTEF         10         20         30         40         50         60
MDRMKKIKRQ LSMTLRGGRG IDKTNGAPEQ IGLDESGGGG GSDPGEAPTR AAPGELRSAR
        70         80         90        100        110        120
GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL
       130        140        150        160        170        180
PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY
       190        200        210        220        230        240
KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF
       250        260        270        280        290        300
EYLDKDLKQY LDDCGNIINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL
       310        320        330        340        350        360
KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP
       370        380        390        400        410        420
LFPGSTVEEQ LHFIFRILGT PTEETWPGIL SNEEFKTYNY PKYRAEALLS HAPRLDSDGA
       430        440        450        460        470        480
DLLTKLLQFE GRNRISAEDA MKHPFFLSLG ERIHKLPDTT SIFALKEIQL QKEASLRSSS
       490
MPDSGRPAFR VVDTEF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00536-1-unknown	MDRMKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00536-1-unknown	MDRMKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107311
Q00536-1-unknown	MDRMKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107312
Q00536-65-unknown	SAPEIV...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177109
Q00536-65-unknown	SAPEIV...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177110
Q00536-65-	SAPEIV...	65		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00536-192-unknown	ALKEIR...	192	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10172
Q00536-192-unknown	ALKEIR...	192	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146528
Q00536-192-unknown	ALKEIR...	192	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149026

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TDNLVA	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10172
...TDNLVA	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129836
...TDNLVA	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132409
...VDTEF	496	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VDTEF	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65713
...VDTEF	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65712

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	191	NLVA.\|.ALKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)