Q00653: Nuclear factor NF-kappa-B p100 subunit

General Information

Protein names	- Nuclear factor NF-kappa-B p100 subunit - DNA-binding factor KBF2 - H2TF1 - Lymphocyte translocation chromosome 10 protein - Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 - Oncogene Lyt-10 - Lyt10 - Nuclear factor NF-kappa-B p52 subunit
Gene names	NFKB2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00653

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 3 of Nuclear factor NF-kappa-B p100 subunit - Isoform 4 of Nuclear factor NF-kappa-B p100 subunit

Sequence View

        10         20         30         40         50         60
MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG FRFRYGCEGP
        70         80         90        100        110        120
SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD PPRAHAHSLV GKQCSELGIC
       130        140        150        160        170        180
AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM IQKLQRQRLR SRPQGLTEAE QRELEQEAKE
       190        200        210        220        230        240
LKKVMDLSIV RLRFSAFLRA SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV
       250        260        270        280        290        300
RGGDEVYLLC DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE
       310        320        330        340        350        360
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF GGGSHMGGGS
       370        380        390        400        410        420
GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG GGGGAQMAAT VPSRDSGEEA
       430        440        450        460        470        480
AEPSAPSRTP QCEPQAPEML QRAREYNARL FGLAQRSARA LLDYGVTADA RALLAGQRHL
       490        500        510        520        530        540
LTAQDENGDT PLHLAIIHGQ TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT
       550        560        570        580        590        600
SVVSFLLRVG ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG
       610        620        630        640        650        660
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV THLVTKLRAN
       670        680        690        700        710        720
VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE PLCPLPSPPT SDSDSDSEGP
       730        740        750        760        770        780
EKDTRSSFRG HTPLDLTCST KVKTLLLNAA QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ
       790        800        810        820        830        840
LLDGPEAQGS WAELAERLGL RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL
       850        860        870        880        890        900
EEGVRLLRGP ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH

        10         20         30         40         50         60
MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG FRFRYGCEGP
        70         80         90        100        110        120
SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD PPRAHAHSLV GKQCSELGIC
       130        140        150        160        170        180
AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM IQKLQRQRLR SRPQGLTEAE QRELEQEAKE
       190        200        210        220        230        240
LKKVMDLSIV RLRFSAFLRA SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV
       250        260        270        280        290        300
RGGDEVYLLC DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE
       310        320        330        340        350        360
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF GGGSHMGGGS
       370        380        390        400        410        420
GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG GGGGAQMAAT VPSRDSGEEA
       430        440        450        460        470        480
AEPSAPSRTP QCEPQAPEML QRAREYNARL FGLAQRSARA LLDYGVTADA RALLAGQRHL
       490        500        510        520        530        540
LTAQDENGDT PLHLAIIHGQ TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT
       550        560        570        580        590        600
SVVSFLLRVG ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG
       610        620        630        640        650        660
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV THLVTKLRAN
       670        680        690        700        710        720
VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE PLCPLPSPPT SDSDSDSEGP
       730        740        750        760        770        780
EKDTRSSFRG HTPLDLTCST KVKTLLLNAA QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ
       790        800        810        820        830        840
LLDGPEAQGS WAELAERLGL RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL
       850        860        870        880        890        900
EEGVRLLRGP ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00653-1-unknown	MESCYN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00653-1-unknown	MESCYN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82784
Q00653-1-unknown	MESCYN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82785
Q00653-11-unknown	GIIEYD...	11		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00653-11-unknown	GIIEYD...	11	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161875
Q00653-11-unknown	GIIEYD...	11	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161876
Q00653-11-	GIIEYD...	11		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q00653-11-	GIIEYD...	11		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00653-11-	GIIEYD...	11		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q00653-11-	GIIEYD...	11		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00653-11-	GIIEYD...	11		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00653-23-	SIVEPK...	23		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00653-23-unknown	SIVEPK...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176783
Q00653-23-unknown	SIVEPK...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176784

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFGLAQ	454	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFGLAQ	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92816
...QPQVH	900	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QPQVH	900	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78403

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)