Q00987: E3 ubiquitin-protein ligase Mdm2

General Information

Protein names	- E3 ubiquitin-protein ligase Mdm2 - 2.3.2.27 {ECO:0000269\|PubMed:12821780} - Double minute 2 protein - Hdm2 - Oncoprotein Mdm2 - RING-type E3 ubiquitin transferase Mdm2 {ECO:0000305} - p53-binding protein Mdm2
Gene names	MDM2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00987

6 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Mdm2-A of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-A1 of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-B of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-C of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-D of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-E of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-alpha of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-F of E3 ubiquitin-protein ligase Mdm2 - Isoform Mdm2-G of E3 ubiquitin-protein ligase Mdm2 - Isoform 11 of E3 ubiquitin-protein ligase Mdm2

Sequence View

        10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P         10         20         30         40         50         60
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY
        70         80         90        100        110        120
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT
       130        140        150        160        170        180
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ
       190        200        210        220        230        240
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
       250        260        270        280        290        300
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
       310        320        330        340        350        360
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP
       370        380        390        400        410        420
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ
       430        440        450        460        470        480
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
       490
PIQMIVLTYF P

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00987-1-unknown	MCNTNM...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80723
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80724
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80725
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80726
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80727
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80728
Q00987-1-unknown	MCNTNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80730
Q00987-6-unknown	MSVPTD...	6	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000335096
Q00987-6-unknown	MSVPTD...	6	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430906
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194702
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194703
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194704
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194705
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194706
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194707
Q00987-6-unknown	MSVPTD...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194708
Q00987-62-unknown	MTKRLY...	62	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80729
Q00987-164-	AISETE...	164		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00987-164-unknown	AISETE...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176945
Q00987-164-unknown	AISETE...	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176944
Q00987-362-unknown	CKKTIV...	362	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2614
Q00987-362-unknown	CKKTIV...	362	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2885
Q00987-362-unknown	CKKTIV...	362	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1991
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141754
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144339
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145407
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146304
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149881
Q00987-362-unknown	CKKTIV...	362	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150264

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DESLAL	198	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000377068
...DESLAL	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155592
...DESLAL	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155591
...SLDSED	257	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444430
...LADYWK	303	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000377067
...NEMNPP	313	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427828
...FDVPDC	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2614
...FDVPDC	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2885
...FDVPDC	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1991
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124937
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127601
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128700
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129607
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133272
...FDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133657
...LTYFP	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76345
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76343
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76342
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76341
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76344
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76347
...LTYFP	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76348

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	361	VPDC.\|.CKKT	inferred from experiment	unknown	MEROPS	Cooper GM	Erhardt P et al.:Identification of the MDM2 onco... (C14.003)	9182520,
CASP7_HUMAN	361	VPDC.\|.CKKT	inferred from experiment	unknown	MEROPS	Cooper GM	Erhardt P et al.:Identification of the MDM2 onco... (C14.003)	9182520,
CASP3_HUMAN	361	VPDC.\|.CKKT	inferred from experiment	unknown	MEROPS	Cooper GM	Erhardt P et al.:Identification of the MDM2 onco... (C14.003)	9182520,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)