Q01804: OTU domain-containing protein 4

General Information

Protein names	- OTU domain-containing protein 4 - 3.4.19.12 {ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:25944111, ECO:0000269\|PubMed:29395066} - HIV-1-induced protein HIN-1 {ECO:0000303\|PubMed:1475186}
Gene names	OTUD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01804

10 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of OTU domain-containing protein 4 - Isoform 3 of OTU domain-containing protein 4 - Isoform 4 of OTU domain-containing protein 4

Sequence View

        10         20         30         40         50         60
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR
        70         80         90        100        110        120
HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY
       130        140        150        160        170        180
REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD
       190        200        210        220        230        240
VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS
       250        260        270        280        290        300
LPLSRKVLKS LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF
       310        320        330        340        350        360
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST SGQNFHSDVD
       370        380        390        400        410        420
YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ SQKFSSEHKN LSRTPSQIIR
       430        440        450        460        470        480
KPDRERVEDF DHTSRESNYF GLSPEERREK QAIEESRLLY EIQNRDEQAF PALSSSSVNQ
       490        500        510        520        530        540
SASQSSNPCV QRKSSHVGDR KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK
       550        560        570        580        590        600
YATVSSPSKS KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE
       610        620        630        640        650        660
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP LMPLPQTLSL
       670        680        690        700        710        720
YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR FFFNLGVKAY SCPMWAPHSY
       730        740        750        760        770        780
LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ EAPAAQNESD CTCTDAHFPM QTEASVNGQM
       790        800        810        820        830        840
PQPEIGPPTF SSPLVIPPSQ VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP
       850        860        870        880        890        900
SFGPNPFLGP VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS
       910        920        930        940        950        960
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL ASIPPVAEGK
       970        980        990       1000       1010       1020
AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT AADVVSPGAN SVDSRVQRPK
      1030       1040       1050       1060       1070       1080
EESSEDENEV SNILRSGRSK QFYNQTYGSR KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS
      1090       1100       1110
RDEGYQYHRN VRGRPFRGDR RRSGMGDGHR GQHT         10         20         30         40         50         60
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR
        70         80         90        100        110        120
HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY
       130        140        150        160        170        180
REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD
       190        200        210        220        230        240
VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS
       250        260        270        280        290        300
LPLSRKVLKS LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF
       310        320        330        340        350        360
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST SGQNFHSDVD
       370        380        390        400        410        420
YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ SQKFSSEHKN LSRTPSQIIR
       430        440        450        460        470        480
KPDRERVEDF DHTSRESNYF GLSPEERREK QAIEESRLLY EIQNRDEQAF PALSSSSVNQ
       490        500        510        520        530        540
SASQSSNPCV QRKSSHVGDR KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK
       550        560        570        580        590        600
YATVSSPSKS KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE
       610        620        630        640        650        660
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP LMPLPQTLSL
       670        680        690        700        710        720
YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR FFFNLGVKAY SCPMWAPHSY
       730        740        750        760        770        780
LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ EAPAAQNESD CTCTDAHFPM QTEASVNGQM
       790        800        810        820        830        840
PQPEIGPPTF SSPLVIPPSQ VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP
       850        860        870        880        890        900
SFGPNPFLGP VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS
       910        920        930        940        950        960
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL ASIPPVAEGK
       970        980        990       1000       1010       1020
AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT AADVVSPGAN SVDSRVQRPK
      1030       1040       1050       1060       1070       1080
EESSEDENEV SNILRSGRSK QFYNQTYGSR KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS
      1090       1100       1110
RDEGYQYHRN VRGRPFRGDR RRSGMGDGHR GQHT         10         20         30         40         50         60
MEAAVGVPDG GDQGGAGPRE DATPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR
        70         80         90        100        110        120
HVEVRMACIH YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFIIY
       130        140        150        160        170        180
REPNVSPSQV TENNFPEKVL LCFSNGNHYD IVYPIKYKES SAMCQSLLYE LLYEKVFKTD
       190        200        210        220        230        240
VSKIVMELDT LEVADEDNSE ISDSEDDSCK SKTAAAAADV NGFKPLSGNE QLKNNGNSTS
       250        260        270        280        290        300
LPLSRKVLKS LNPAVYRNVE YEIWLKSKQA QQKRDYSIAA GLQYEVGDKC QVRLDHNGKF
       310        320        330        340        350        360
LNADVQGIHS ENGPVLVEEL GKKHTSKNLK APPPESWNTV SGKKMKKPST SGQNFHSDVD
       370        380        390        400        410        420
YRGPKNPSKP IKAPSALPPR LQHPSGVRQH AFSSHSSGSQ SQKFSSEHKN LSRTPSQIIR
       430        440        450        460        470        480
KPDRERVEDF DHTSRESNYF GLSPEERREK QAIEESRLLY EIQNRDEQAF PALSSSSVNQ
       490        500        510        520        530        540
SASQSSNPCV QRKSSHVGDR KGSRRRMDTE ERKDKDSIHG HSQLDKRPEP STLENITDDK
       550        560        570        580        590        600
YATVSSPSKS KKLECPSPAE QKPAEHVSLS NPAPLLVSPE VHLTPAVPSL PATVPAWPSE
       610        620        630        640        650        660
PTTFGPTGVP APIPVLSVTQ TLTTGPDSAV SQAHLTPSPV PVSIQAVNQP LMPLPQTLSL
       670        680        690        700        710        720
YQDPLYPGFP CNEKGDRAIV PPYSLCQTGE DLPKDKNILR FFFNLGVKAY SCPMWAPHSY
       730        740        750        760        770        780
LYPLHQAYLA ACRMYPKVPV PVYPHNPWFQ EAPAAQNESD CTCTDAHFPM QTEASVNGQM
       790        800        810        820        830        840
PQPEIGPPTF SSPLVIPPSQ VSESHGQLSY QADLESETPG QLLHADYEES LSGKNMFPQP
       850        860        870        880        890        900
SFGPNPFLGP VPIAPPFFPH VWYGYPFQGF IENPVMRQNI VLPSDEKGEL DLSLENLDLS
       910        920        930        940        950        960
KDCGSVSTVD EFPEARGEHV HSLPEASVSS KPDEGRTEQS SQTRKADTAL ASIPPVAEGK
       970        980        990       1000       1010       1020
AHPPTQILNR ERETVPVELE PKRTIQSLKE KTEKVKDPKT AADVVSPGAN SVDSRVQRPK
      1030       1040       1050       1060       1070       1080
EESSEDENEV SNILRSGRSK QFYNQTYGSR KYKSDWGYSG RGGYQHVRSE ESWKGQPSRS
      1090       1100       1110
RDEGYQYHRN VRGRPFRGDR RRSGMGDGHR GQHT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01804-1-Acetylation	MEAAVG...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01804-1-Acetylation	MEAAVG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q01804-1-Acetylation	MEAAVG...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01804-1-Acetylation	MEAAVG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q01804-10-	GGDQGG...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01804-66-unknown	MACIHY...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83919
Q01804-66-unknown	MACIHY...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83920
Q01804-66-unknown	MACIHY...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83921
Q01804-66-unknown	MACIHY...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409279
Q01804-66-unknown	MACIHY...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425972
Q01804-66-unknown	MACIHY...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424192
Q01804-66-unknown	MACIHY...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423453
Q01804-66-unknown	MACIHY...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000296579
Q01804-904-unknown	GSVSTV...	904		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171460
Q01804-904-unknown	GSVSTV...	904		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171459
Q01804-904-	GSVSTV...	904			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01804-926-unknown	ASVSSK...	926		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173776
Q01804-926-unknown	ASVSSK...	926		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173775
Q01804-926-	ASVSSK...	926			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01804-951-	ASIPPV...	951			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q01804-951-unknown	ASIPPV...	951		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168607
Q01804-951-unknown	ASIPPV...	951		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168606
Q01804-999-unknown	KTAADV...	999		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14354
Q01804-999-unknown	KTAADV...	999		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157014
Q01804-999-unknown	KTAADV...	999		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157017

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EISDSE	204	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423453
...EISDSE	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155668
...EISDSE	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155669
...EISDSE	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155670
...DDSCKS	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79539
...DDSCKS	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424192
...DDSCKS	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000296579
...DDSCKS	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91685
...DDSCKS	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91686
...SRESNY	438	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425972
...KVKDPK	998	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14354
...KVKDPK	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140506
...KVKDPK	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140509
...RGQHT	1114	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RGQHT	1114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79537
...RGQHT	1114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79538

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	998	KDPK.\|.KTAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)