TopFIND 4.0

Q05932: Folylpolyglutamate synthase, mitochondrial

General Information

Protein names
- Folylpolyglutamate synthase, mitochondrial
- 6.3.2.17
- Folylpoly-gamma-glutamate synthetase
- FPGS
- Tetrahydrofolylpolyglutamate synthase
- Tetrahydrofolate synthase

Gene names FPGS
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q05932

6

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG 
        70         80         90        100        110        120 
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 
       130        140        150        160        170        180 
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 
       190        200        210        220        230        240 
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 
       250        260        270        280        290        300 
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 
       310        320        330        340        350        360 
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 
       370        380        390        400        410        420 
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 
       430        440        450        460        470        480 
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 
       490        500        510        520        530        540 
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 
       550        560        570        580    
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ

Isoforms

- Isoform 2 of Folylpolyglutamate synthase, mitochondrial - Isoform 3 of Folylpolyglutamate synthase, mitochondrial - Isoform 4 of Folylpolyglutamate synthase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG 
        70         80         90        100        110        120 
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 
       130        140        150        160        170        180 
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 
       190        200        210        220        230        240 
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 
       250        260        270        280        290        300 
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 
       310        320        330        340        350        360 
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 
       370        380        390        400        410        420 
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 
       430        440        450        460        470        480 
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 
       490        500        510        520        530        540 
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 
       550        560        570        580    
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ         10         20         30         40         50         60 
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG 
        70         80         90        100        110        120 
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 
       130        140        150        160        170        180 
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 
       190        200        210        220        230        240 
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 
       250        260        270        280        290        300 
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 
       310        320        330        340        350        360 
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 
       370        380        390        400        410        420 
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 
       430        440        450        460        470        480 
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 
       490        500        510        520        530        540 
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 
       550        560        570        580    
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ         10         20         30         40         50         60 
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG 
        70         80         90        100        110        120 
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 
       130        140        150        160        170        180 
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 
       190        200        210        220        230        240 
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 
       250        260        270        280        290        300 
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 
       310        320        330        340        350        360 
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 
       370        380        390        400        410        420 
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 
       430        440        450        460        470        480 
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 
       490        500        510        520        530        540 
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 
       550        560        570        580    
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ



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(REFRESH)

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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)