Q05932: Folylpolyglutamate synthase, mitochondrial

General Information

Protein names	- Folylpolyglutamate synthase, mitochondrial - 6.3.2.17 - Folylpoly-gamma-glutamate synthetase - FPGS - Tetrahydrofolylpolyglutamate synthase - Tetrahydrofolate synthase
Gene names	FPGS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05932

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Folylpolyglutamate synthase, mitochondrial - Isoform 3 of Folylpolyglutamate synthase, mitochondrial - Isoform 4 of Folylpolyglutamate synthase, mitochondrial

Sequence View

        10         20         30         40         50         60
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG
        70         80         90        100        110        120
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS
       130        140        150        160        170        180
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW
       370        380        390        400        410        420
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD
       430        440        450        460        470        480
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE
       490        500        510        520        530        540
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP
       550        560        570        580
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ         10         20         30         40         50         60
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG
        70         80         90        100        110        120
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS
       130        140        150        160        170        180
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW
       370        380        390        400        410        420
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD
       430        440        450        460        470        480
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE
       490        500        510        520        530        540
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP
       550        560        570        580
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ         10         20         30         40         50         60
MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG
        70         80         90        100        110        120
YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS
       130        140        150        160        170        180
YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF
       190        200        210        220        230        240
LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA
       250        260        270        280        290        300
WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE
       310        320        330        340        350        360
HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW
       370        380        390        400        410        420
PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD
       430        440        450        460        470        480
PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE
       490        500        510        520        530        540
QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP
       550        560        570        580
PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q05932-1-unknown	MSRARS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75359
Q05932-33-	SAWPVP...	33			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q05932-33-	SAWPVP...	33			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q05932-33-unknown	SAWPVP...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173903
Q05932-43-unknown	MEYQDA...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75357
Q05932-43-unknown	MEYQDA...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101157
Q05932-43-Acetylation	MEYQDA...	43	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q05932-43-Acetylation	MEYQDA...	43	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115487
Q05932-43-Acetylation	MEYQDA...	43	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115486
Q05932-51-unknown	MLNTLQ...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75358
Q05932-51-unknown	MLNTLQ...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101225
Q05932-51-unknown	MLNTLQ...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101224

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PALSQ	587	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PALSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70976
...PALSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70975
...PALSQ	587	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70977

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)