Q06203: Amidophosphoribosyltransferase

General Information

Protein names	- Amidophosphoribosyltransferase - ATase - 2.4.2.14 - Glutamine phosphoribosylpyrophosphate amidotransferase - GPAT
Gene names	PPAT
Organism	Homo sapiens
Protease Family
Protease ID	C44.001
Chromosome location
UniProt ID	Q06203

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELEELGIRE ECGVFGCIAS GEWPTQLDVP HVITLGLVGL QHRGQESAGI VTSDGSSVPT
        70         80         90        100        110        120
FKSHKGMGLV NHVFTEDNLK KLYVSNLGIG HTRYATTGKC ELENCQPFVV ETLHGKIAVA
       130        140        150        160        170        180
HNGELVNAAR LRKKLLRHGI GLSTSSDSEM ITQLLAYTPP QEQDDTPDWV ARIKNLMKEA
       190        200        210        220        230        240
PTAYSLLIMH RDVIYAVRDP YGNRPLCIGR LIPVSDINDK EKKTSETEGW VVSSESCSFL
       250        260        270        280        290        300
SIGARYYREV LPGEIVEISR HNVQTLDIIS RSEGNPVAFC IFEYVYFARP DSMFEDQMVY
       310        320        330        340        350        360
TVRYRCGQQL AIEAPVDADL VSTVPESATP AALAYAGKCG LPYVEVLCKN RYVGRTFIQP
       370        380        390        400        410        420
NMRLRQLGVA KKFGVLSDNF KGKRIVLVDD SIVRGNTISP IIKLLKESGA KEVHIRVASP
       430        440        450        460        470        480
PIKYPCFMGI NIPTKEELIA NKPEFDHLAE YLGANSVVYL SVEGLVSSVQ EGIKFKKQKE
       490        500        510
KKHDIMIQEN GNGLECFEKS GHCTACLTGK YPVELEW

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06203-1-acetylation	MELEEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q06203-12-unknown	CGVFGC...	12		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06203-29-	VPHVIT...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q06203-86-unknown	NLGIGH...	86		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3966

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KLYVSN	85	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3966
	...VELEW	517	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	85	YVSN.\|.NLGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)