Q08170: Serine/arginine-rich splicing factor 4

General Information

Protein names	- Serine/arginine-rich splicing factor 4 - Pre-mRNA-splicing factor SRP75 - SRP001LB - Splicing factor, arginine/serine-rich 4
Gene names	SRSF4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q08170

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD AVYELNGKDL
        70         80         90        100        110        120
CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT RTEYRLIVEN LSSRCSWQDL
       130        140        150        160        170        180
KDYMRQAGEV TYADAHKGRK NEGVIEFVSY SDMKRALEKL DGTEVNGRKI RLVEDKPGSR
       190        200        210        220        230        240
RRRSYSRSRS HSRSRSRSRH SRKSRSRSGS SKSSHSKSRS RSRSGSRSRS KSRSRSQSRS
       250        260        270        280        290        300
RSKKEKSRSP SKEKSRSRSH SAGKSRSKSK DQAEEKIQNN DNVGKPKSRS PSRHKSKSKS
       310        320        330        340        350        360
RSRSQERRVE EEKRGSVSRG RSQEKSLRQS RSRSRSKGGS RSRSRSRSKS KDKRKGRKRS
       370        380        390        400        410        420
REESRSRSRS RSKSERSRKR GSKRDSKAGS SKKKKKEDTD RSQSRSPSRS VSKEREHAKS
       430        440        450        460        470        480
ESSQREGRGE SENAGTNQET RSRSRSNSKS KPNLPSESRS RSKSASKTRS RSKSRSRSAS
       490
RSPSRSRSRS HSRS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q08170-1-unknown	MPRVYI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q08170-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q08170-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q08170-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q08170-106-unknown	LIVENL...	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10216

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RTEYRL	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10216
	...SHSRS	494	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	105	EYRL.\|.LIVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)