Q12792: Twinfilin-1

General Information

Protein names	- Twinfilin-1 - Protein A6 - Protein tyrosine kinase 9
Gene names	TWF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12792

5 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 3 of Twinfilin-1 - Isoform 4 of Twinfilin-1

Sequence View

        10         20         30         40         50         60
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD KDYDSFVLPL
        70         80         90        100        110        120
LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE
       130        140        150        160        170        180
VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVGVDT KHQTLQGVAF
       190        200        210        220        230        240
PISREAFQAL EKLNNRQLNY VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL
       250        260        270        280        290        300
YKHSHEGDYL ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG
       310        320        330        340        350
DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD         10         20         30         40         50         60
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD KDYDSFVLPL
        70         80         90        100        110        120
LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE
       130        140        150        160        170        180
VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVGVDT KHQTLQGVAF
       190        200        210        220        230        240
PISREAFQAL EKLNNRQLNY VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL
       250        260        270        280        290        300
YKHSHEGDYL ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG
       310        320        330        340        350
DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q12792-1-unknown	MSHQTG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93457
Q12792-2-unknown	MSHQTG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12792-2-Acetylation	SHQTGI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12792-2-Acetylation	SHQTGI...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q12792-2-Acetylation	SHQTGI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111393
Q12792-99-unknown	MLYAAT...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93458
Q12792-99-unknown	MLYAAT...	99		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448750
Q12792-99-unknown	MLYAAT...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96949
Q12792-166-unknown	VGVDTK...	166		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11953
Q12792-166-unknown	VGVDTK...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140510
Q12792-166-unknown	VGVDTK...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196460

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KKYLLS	139	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446696
...KKYLLS	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt114452
...KKYLLS	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt114451
...EVQTDV	165	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11953
...EVQTDV	165	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123641
...YLESIV	253	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448221
...YLESIV	253	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt114449
...YLESIV	253	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt114448
...EATTD	350	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EATTD	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89076
...EATTD	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89075
...	368		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	165	QTDV.\|.VGVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)