Q13043: Serine/threonine-protein kinase 4

General Information

Protein names	- Serine/threonine-protein kinase 4 - 2.7.11.1 - Mammalian STE20-like protein kinase 1 - MST-1 - STE20-like kinase MST1 - Serine/threonine-protein kinase Krs-2 - Serine/threonine-protein kinase 4 37kDa subunit - MST1/N - Serine/threonine-protein kinase 4 18kDa subunit - MST1/C
Gene names	STK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13043

13 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ
        70         80         90        100        110        120
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT
       130        140        150        160        170        180
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK
       190        200        210        220        230        240
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP
       250        260        270        280        290        300
PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV
       310        320        330        340        350        360
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT
       370        380        390        400        410        420
LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK
       430        440        450        460        470        480
NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK

KRRQQNF

Isoforms

- Isoform 2 of Serine/threonine-protein kinase 4

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

13 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13043-1-Acetylation	METVQL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13043-1-Acetylation	METVQL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13043-1-Acetylation	METVQL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13043-1-Acetylation	METVQL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13043-1-Acetylation	METVQL...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100717
Q13043-1-unknown	METVQL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90934
Q13043-16-unknown	KLDEDS...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173517
Q13043-16-	KLDEDS...	16			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13043-16-	KLDEDS...	16			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13043-21-unknown	SLTKQP...	21		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173519
Q13043-21-	SLTKQP...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13043-21-	SLTKQP...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13043-327-unknown	SGTMVR...	327		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13043-327-unknown	SGTMVR...	327		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2149
Q13043-327-unknown	SGTMVR...	327		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116158
Q13043-350-unknown	GANTMI...	350		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2151
Q13043-350-unknown	GANTMI...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150940
Q13043-350-	GANTMI...	350			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13043-350-	GANTMI...	350			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13043-350-	GANTMI...	350			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13043-353-unknown	TMIEHD...	353		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175089
Q13043-353-	TMIEHD...	353			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13043-354-unknown	MIEHDD...	354		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175091
Q13043-354-	MIEHDD...	354			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13043-354-	MIEHDD...	354			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDEMDS	326	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDEMDS	326	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2149
...EDEMDS	326	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92402
...STMTDG	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2151
...STMTDG	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134342
...RQQNF	487	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	326	EMDS.\|.SGTM	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,
CASP3_HUMAN	349	MTDG.\|.GANT	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)