TopFIND 4.0

Q13541: Eukaryotic translation initiation factor 4E-binding protein 1

General Information

Protein names	- Eukaryotic translation initiation factor 4E-binding protein 1 - 4E-BP1 - eIF4E-binding protein 1 - Phosphorylated heat- and acid-stable protein regulated by insulin 1 - PHAS-I
Gene names	EIF4EBP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13541

4

N-termini

3

C-termini

1

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM
70 80 90 100 110
ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13541-2-unknown	MSGGSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13541-2-Acetylation	SGGSSC...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13541-2-Acetylation	SGGSSC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13541-2-Acetylation	SGGSSC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13541-26-unknown	GVQLPP...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2192
Q13541-26-unknown	GVQLPP...	26			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q13541-26-	GVQLPP...	26			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...VVLGDG	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2192
	...FEMDI	118	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...FEMDI	118		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
	...FEMDI	118		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
	...FEMDI	118		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
	...FEMDI	118		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	25	LGDG.\|.GVQL	inferred from experiment	unknown	MEROPS	Proud CG	Tee AR et al.:Caspase cleavage of initiation ... (C14.003)	11865047,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)