Q13614: Myotubularin-related protein 2

General Information

Protein names	- Myotubularin-related protein 2 - Phosphatidylinositol-3,5-bisphosphate 3-phosphatase - 3.1.3.95 {ECO:0000269\|PubMed:12668758, ECO:0000269\|PubMed:14690594, ECO:0000269\|PubMed:21372139} - Phosphatidylinositol-3-phosphate phosphatase - 3.1.3.64 {ECO:0000269\|PubMed:11733541, ECO:0000269\|PubMed:12668758, ECO:0000269\|PubMed:14690594, ECO:0000269\|PubMed:21372139}
Gene names	MTMR2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13614

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSADNFSPD
        70         80         90        100        110        120
LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD
       130        140        150        160        170        180
PPFVLDASLG VINRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM
       190        200        210        220        230        240
KYAFPVSNNL PLFAFEYKEV FPENGWKLYD PLLEYRRQGI PNESWRITKI NERYELCDTY
       250        260        270        280        290        300
PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE
       310        320        330        340        350        360
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR
       370        380        390        400        410        420
ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADKVESGK TSVVVHCSDG
       430        440        450        460        470        480
WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE KEWLSFGHRF QLRVGHGDKN HADADRSPVF
       490        500        510        520        530        540
LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPKRTVSL
       550        560        570        580        590        600
WSYINSQLED FTNPLYGSYS NHVLYPVASM RHLELWVGYY IRWNPRMKPQ EPIHNRYKEL
       610        620        630        640
LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV

Isoforms

- Isoform 2 of Myotubularin-related protein 2

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13614-1-unknown	MEKSSS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13614-49-	SISTSA...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13614-49-	SISTSA...	49		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13614-49-	SISTSA...	49		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13614-49-	SISTSA...	49		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13614-49-	SISTSA...	49		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13614-73-unknown	MEEPPL...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81748

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...VQTVV	643	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...VQTVV	643	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt77366

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)