Q13867: Bleomycin hydrolase
Protein names | - Bleomycin hydrolase - BH - BLM hydrolase - BMH - 3.4.22.40 |
---|---|
Gene names | BLMH |
Organism | Homo sapiens |
Protease Family | C01.084 |
Protease ID | C01.084 |
Chromosome location | |
UniProt ID | Q13867 |
6
N-termini
5
C-termini
1
Cleavages
30
Substrates
Sequence
10 20 30 40 50 60
MSSSGLNSEK VAALIQKLNS DPQFVLAQNV GTTHDLLDIC LKRATVQRAQ HVFQHAVPQE
70 80 90 100 110 120
GKPITNQKSS GRCWIFSCLN VMRLPFMKKL NIEEFEFSQS YLFFWDKVER CYFFLSAFVD
130 140 150 160 170 180
TAQRKEPEDG RLVQFLLMNP ANDGGQWDML VNIVEKYGVI PKKCFPESYT TEATRRMNDI
190 200 210 220 230 240
LNHKMREFCI RLRNLVHSGA TKGEISATQD VMMEEIFRVV CICLGNPPET FTWEYRDKDK
250 260 270 280 290 300
NYQKIGPITP LEFYREHVKP LFNMEDKICL VNDPRPQHKY NKLYTVEYLS NMVGGRKTLY
310 320 330 340 350 360
NNQPIDFLKK MVAASIKDGE AVWFGCDVGK HFNSKLGLSD MNLYDHELVF GVSLKNMNKA
370 380 390 400 410 420
ERLTFGESLM THAMTFTAVS EKDDQDGAFT KWRVENSWGE DHGHKGYLCM TDEWFSEYVY
430 440 450
EVVVDRKHVP EEVLAVLEQE PIILPAWDPM GALAE
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
6 N-termini - 5 C-termini - 1 Cleavages - 30 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q13867-1-Acetylation | MSSSGL... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q13867-2-acetylation | SSSGLN... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q13867-82-unknown | MRLPFM... | 82 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000466527 | |||
Q13867-119-unknown | VDTAQR... | 119 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462442 | |||
Q13867-177-unknown | MNDILN... | 177 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000468681 | |||
Q13867-381-unknown | EKDDQD... | 381 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7793 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GGQWDM | 148 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000466527 | |||
...IKDGEA | 320 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000468486 | |||
...FTAVSE | 380 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7793 | |||
...AVSEKD | 382 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462442 | |||
...GALAE | 455 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATS_HUMAN | 380 | AVSE.|.EKDD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
A4-Isoform10_HUMAN | 554 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform10_HUMAN | 558 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform10_HUMAN | 559 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform3_HUMAN | 592 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform3_HUMAN | 596 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform3_HUMAN | 597 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform4_HUMAN | 610 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform5_HUMAN | 611 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform4_HUMAN | 614 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform5_HUMAN | 615 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform4_HUMAN | 615 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform5_HUMAN | 616 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform6_HUMAN | 629 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform6_HUMAN | 633 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform6_HUMAN | 634 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform7_HUMAN | 648 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform7_HUMAN | 652 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform7_HUMAN | 653 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform11_HUMAN | 661 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform11_HUMAN | 665 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform8_HUMAN | 666 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform11_HUMAN | 666 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform9_HUMAN | 667 | VHHQ.|.QKLV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC611 | ||
A4-Isoform8_HUMAN | 670 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform9_HUMAN | 671 | KLVF.|.FFAE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC621 | ||
A4-Isoform8_HUMAN | 671 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4-Isoform9_HUMAN | 672 | LVFF.|.FAED | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC631 | ||
A4_HUMAN | 685 | VHHQ.|.QKLV | inferred from experiment | unknown | MEROPS | Takeda A | Kajiya A et al.:Processing of amyloid beta-pept... (C01.084) | 16472072, |
A4_HUMAN | 689 | KLVF.|.FFAE | inferred from experiment | unknown | MEROPS | Takeda A | Kajiya A et al.:Processing of amyloid beta-pept... (C01.084) | 16472072, |
A4_HUMAN | 690 | LVFF.|.FAED | inferred from experiment | unknown | MEROPS | Takeda A | Kajiya A et al.:Processing of amyloid beta-pept... (C01.084) | 16472072, |