Q13895: Bystin {ECO:0000305}

General Information

Protein names	- Bystin {ECO:0000305}
Gene names	BYSL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13895

7 N-termini

6 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV GPRLSRRILQ
        70         80         90        100        110        120
QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD EDEEWPTLEK AATMTAAGHH
       130        140        150        160        170        180
AEVVVDPEDE RAIEMFMNKN PPARRTLADI IMEKLTEKQT EVETVMSEVS GFPMPQLDPR
       190        200        210        220        230        240
VLEVYRGVRE VLSKYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN
       250        260        270        280        290        300
LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
       310        320        330        340        350        360
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY ALPYRVLDAL
       370        380        390        400        410        420
VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA LLELLRLQPH PQLSPEIRRE
       430
LQSAVPRDVE DVPITVE

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13895-1-unknown	MPKFKA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13895-2-unknown	PKFKAA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13895-2-unknown	PKFKAA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13895-20-	ADQILA...	20		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13895-20-	ADQILA...	20		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q13895-20-unknown	ADQILA...	20	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14468
Q13895-20-unknown	ADQILA...	20		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13895-22-unknown	QILAGN...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12115
Q13895-70-unknown	EAEHGT...	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14469
Q13895-73-unknown	HGTGDK...	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12116

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KHAPLA	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14468
...APLADQ	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12115
...QQEELE	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14469
...ELEAEH	72	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12116
...PITVE	437		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PITVE	437		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PITVE	437	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PITVE	437		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PITVE	437		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	19	APLA.\|.ADQI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	21	LADQ.\|.QILA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	69	EELE.\|.EAEH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	72	EAEH.\|.HGTG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)