Q14126: Desmoglein-2
| Protein names | - Desmoglein-2 - Cadherin family member 5 - HDGC |
|---|---|
| Gene names | DSG2 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q14126 |
5
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE
70 80 90 100 110 120
GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE
130 140 150 160 170 180
ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK
190 200 210 220 230 240
INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE
250 260 270 280 290 300
ARDGNGEVTD KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE
310 320 330 340 350 360
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF SVIVANKAAF
370 380 390 400 410 420
HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES MDRSSKGQII GNFQAFDEDT
430 440 450 460 470 480
GLPAHARYVK LEDRDNWISV DSVTSEIKLA KLPDFESRYV QNGTYTVKIV AISEDYPRKT
490 500 510 520 530 540
ITGTVLINVE DINDNCPTLI EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM
550 560 570 580 590 600
AEKWKIARQE STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR
610 620 630 640 650 660
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT IEMLHPWNNE
670 680 690 700 710 720
GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS SASIVKGQHE MSEMDGRWEE
730 740 750 760 770 780
HRSLLSGRAT QFTGATGAIM TTETTKTARA TGASRDMAGA QAAAVALNEE FLRNYFTDKA
790 800 810 820 830 840
ASYTEEDENH TAKDCLLVYS QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC
850 860 870 880 890 900
LGQKIDINKE IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE
910 920 930 940 950 960
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT VILGPSQPQS
970 980 990 1000 1010 1020
LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN PLEGTQHLQD VPYVMVRERE
1030 1040 1050 1060 1070 1080
SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV LAPASTLQSS YQIPTENSMT ARNTTVSGAG
1090 1100 1110
VPGPLPDFGL EESGHSNSTI TTSSTRVTKH STVQHSYS
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q14126-24-unknown | LHLQVL... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q14126-50-unknown | AWITAP... | 50 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q14126-305-unknown | NWLANF... | 305 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12195 | |||
| Q14126-738- | AIMTTE... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
| Q14126-738- | AIMTTE... | 738 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
| Q14126-1034- | AMPNIA... | 1034 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...EIGSDN | 304 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12195 | |||
| ...QHSYS | 1118 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_HUMAN | 304 | GSDN.|.NWLA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|