Q14191: Werner syndrome ATP-dependent helicase

General Information

Protein names	- Werner syndrome ATP-dependent helicase - 3.6.4.12 {ECO:0000269\|PubMed:16622405} - DNA helicase, RecQ-like type 3 - RecQ3 - Exonuclease WRN - 3.1.-.- - RecQ protein-like 2
Gene names	WRN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14191

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEKKLETTA QQRKCPEWMN VQNKRCAVEE RKACVRKSVF EDDLPFLEFT GSIVYSYDAS
        70         80         90        100        110        120
DCSFLSEDIS MSLSDGDVVG FDMEWPPLYN RGKLGKVALI QLCVSESKCY LFHVSSMSVF
       130        140        150        160        170        180
PQGLKMLLEN KAVKKAGVGI EGDQWKLLRD FDIKLKNFVE LTDVANKKLK CTETWSLNSL
       190        200        210        220        230        240
VKHLLGKQLL KDKSIRCSNW SKFPLTEDQK LYAATDAYAG FIIYRNLEIL DDTVQRFAIN
       250        260        270        280        290        300
KEEEILLSDM NKQLTSISEE VMDLAKHLPH AFSKLENPRR VSILLKDISE NLYSLRRMII
       310        320        330        340        350        360
GSTNIETELR PSNNLNLLSF EDSTTGGVQQ KQIREHEVLI HVEDETWDPT LDHLAKHDGE
       370        380        390        400        410        420
DVLGNKVERK EDGFEDGVED NKLKENMERA CLMSLDITEH ELQILEQQSQ EEYLSDIAYK
       430        440        450        460        470        480
STEHLSPNDN ENDTSYVIES DEDLEMEMLK HLSPNDNEND TSYVIESDED LEMEMLKSLE
       490        500        510        520        530        540
NLNSGTVEPT HSKCLKMERN LGLPTKEEEE DDENEANEGE EDDDKDFLWP APNEEQVTCL
       550        560        570        580        590        600
KMYFGHSSFK PVQWKVIHSV LEERRDNVAV MATGYGKSLC FQYPPVYVGK IGLVISPLIS
       610        620        630        640        650        660
LMEDQVLQLK MSNIPACFLG SAQSENVLTD IKLGKYRIVY VTPEYCSGNM GLLQQLEADI
       670        680        690        700        710        720
GITLIAVDEA HCISEWGHDF RDSFRKLGSL KTALPMVPIV ALTATASSSI REDIVRCLNL
       730        740        750        760        770        780
RNPQITCTGF DRPNLYLEVR RKTGNILQDL QPFLVKTSSH WEFEGPTIIY CPSRKMTQQV
       790        800        810        820        830        840
TGELRKLNLS CGTYHAGMSF STRKDIHHRF VRDEIQCVIA TIAFGMGINK ADIRQVIHYG
       850        860        870        880        890        900
APKDMESYYQ EIGRAGRDGL QSSCHVLWAP ADINLNRHLL TEIRNEKFRL YKLKMMAKME
       910        920        930        940        950        960
KYLHSSRCRR QIILSHFEDK QVQKASLGIM GTEKCCDNCR SRLDHCYSMD DSEDTSWDFG
       970        980        990       1000       1010       1020
PQAFKLLSAV DILGEKFGIG LPILFLRGSN SQRLADQYRR HSLFGTGKDQ TESWWKAFSR
      1030       1040       1050       1060       1070       1080
QLITEGFLVE VSRYNKFMKI CALTKKGRNW LHKANTESQS LILQANEELC PKKLLLPSSK
      1090       1100       1110       1120       1130       1140
TVSSGTKEHC YNQVPVELST EKKSNLEKLY SYKPCDKISS GSNISKKSIM VQSPEKAYSS
      1150       1160       1170       1180       1190       1200
SQPVISAQEQ ETQIVLYGKL VEARQKHANK MDVPPAILAT NKILVDMAKM RPTTVENVKR
      1210       1220       1230       1240       1250       1260
IDGVSEGKAA MLAPLLEVIK HFCQTNSVQT DLFSSTKPQE EQKTSLVAKN KICTLSQSMA
      1270       1280       1290       1300       1310       1320
ITYSLFQEKK MPLKSIAESR ILPLMTIGMH LSQAVKAGCP LDLERAGLTP EVQKIIADVI
      1330       1340       1350       1360       1370       1380
RNPPVNSDMS KISLIRMLVP ENIDTYLIHM AIEILKHGPD SGLQPSCDVN KRRCFPGSEE
      1390       1400       1410       1420       1430
ICSSSKRSKE EVGINTETSS AERKRRLPVW FAKGSDTSKK LMDKTKRGGL FS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14191-2-unknown	MSEKKL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14191-2-Acetylation	SEKKLE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14191-2-Acetylation	SEKKLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14191-319-unknown	SFEDST...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14483
Q14191-319-	SFEDST...	319			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14191-1361-unknown	SGLQPS...	1361		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12221

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NLNLLS	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14483
...KHGPDS	1360	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12221
...GGLFS	1432	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	318	NLLS.\|.SFED	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	1360	GPDS.\|.SGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)