TopFIND 4.0

Q14527: Helicase-like transcription factor

General Information

Protein names
- Helicase-like transcription factor
- 2.3.2.27
- 3.6.4.-
- DNA-binding protein/plasminogen activator inhibitor 1 regulator
- HIP116
- RING finger protein 80
- RING-type E3 ubiquitin transferase HLTF {ECO:0000305}
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3
- Sucrose nonfermenting protein 2-like 3
Gene names HLTF
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q14527

11

N-termini

6

C-termini

4

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
        70         80         90        100        110        120 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
       130        140        150        160        170        180 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
       190        200        210        220        230        240 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
       250        260        270        280        290        300 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
       310        320        330        340        350        360 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
       370        380        390        400        410        420 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
       430        440        450        460        470        480 
SETKGRAKAG SSKVIEDVAF ACALTSSVPT TKKKMLKKGA CAVEGSKKTD VEERPRTTLI 
       490        500        510        520        530        540 
ICPLSVLSNW IDQFGQHIKS DVHLNFYVYY GPDRIREPAL LSKQDIVLTT YNILTHDYGT 
       550        560        570        580        590        600 
KGDSPLHSIR WLRVILDEGH AIRNPNAQQT KAVLDLESER RWVLTGTPIQ NSLKDLWSLL 
       610        620        630        640        650        660 
SFLKLKPFID REWWHRTIQR PVTMGDEGGL RRLQSLIKNI TLRRTKTSKI KGKPVLELPE 
       670        680        690        700        710        720 
RKVFIQHITL SDEERKIYQS VKNEGRATIG RYFNEGTVLA HYADVLGLLL RLRQICCHTY 
       730        740        750        760        770        780 
LLTNAVSSNG PSGNDTPEEL RKKLIRKMKL ILSSGSDEEC AICLDSLTVP VITHCAHVFC 
       790        800        810        820        830        840 
KPCICQVIQN EQPHAKCPLC RNDIHEDNLL ECPPEELARD SEKKSDMEWT SSSKINALMH 
       850        860        870        880        890        900 
ALTDLRKKNP NIKSLVVSQF TTFLSLIEIP LKASGFVFTR LDGSMAQKKR VESIQCFQNT 
       910        920        930        940        950        960 
EAGSPTIMLL SLKAGGVGLN LSAASRVFLM DPAWNPAAED QCFDRCHRLG QKQEVIITKF 
       970        980        990       1000    
IVKDSVEENM LKIQNKKREL AAGAFGTKKP NADEMKQAKI NEIRTLIDL

Isoforms

- Isoform 2 of Helicase-like transcription factor

Sequence View

        10         20         30         40         50         60 
MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
        70         80         90        100        110        120 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
       130        140        150        160        170        180 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
       190        200        210        220        230        240 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
       250        260        270        280        290        300 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
       310        320        330        340        350        360 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
       370        380        390        400        410        420 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
       430        440        450        460        470        480 
SETKGRAKAG SSKVIEDVAF ACALTSSVPT TKKKMLKKGA CAVEGSKKTD VEERPRTTLI 
       490        500        510        520        530        540 
ICPLSVLSNW IDQFGQHIKS DVHLNFYVYY GPDRIREPAL LSKQDIVLTT YNILTHDYGT 
       550        560        570        580        590        600 
KGDSPLHSIR WLRVILDEGH AIRNPNAQQT KAVLDLESER RWVLTGTPIQ NSLKDLWSLL 
       610        620        630        640        650        660 
SFLKLKPFID REWWHRTIQR PVTMGDEGGL RRLQSLIKNI TLRRTKTSKI KGKPVLELPE 
       670        680        690        700        710        720 
RKVFIQHITL SDEERKIYQS VKNEGRATIG RYFNEGTVLA HYADVLGLLL RLRQICCHTY 
       730        740        750        760        770        780 
LLTNAVSSNG PSGNDTPEEL RKKLIRKMKL ILSSGSDEEC AICLDSLTVP VITHCAHVFC 
       790        800        810        820        830        840 
KPCICQVIQN EQPHAKCPLC RNDIHEDNLL ECPPEELARD SEKKSDMEWT SSSKINALMH 
       850        860        870        880        890        900 
ALTDLRKKNP NIKSLVVSQF TTFLSLIEIP LKASGFVFTR LDGSMAQKKR VESIQCFQNT 
       910        920        930        940        950        960 
EAGSPTIMLL SLKAGGVGLN LSAASRVFLM DPAWNPAAED QCFDRCHRLG QKQEVIITKF 
       970        980        990       1000    
IVKDSVEENM LKIQNKKREL AAGAFGTKKP NADEMKQAKI NEIRTLIDL



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Protein Neighborhood

Domains & Features

11 N-termini - 6 C-termini - 4 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)