Q14690: Protein RRP5 homolog

General Information

Protein names	- Protein RRP5 homolog - NF-kappa-B-binding protein - NFBP - Programmed cell death protein 11
Gene names	PDCD11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14690

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANLEESFPR GGTRKIHKPE KAFQQSVEQD NLFDISTEEG STKRKKSQKG PAKTKKLKIE
        70         80         90        100        110        120
KRESSKSARE KFEILSVESL CEGMRILGCV KEVNELELVI SLPNGLQGFV QVTEICDAYT
       130        140        150        160        170        180
KKLNEQVTQE QPLKDLLHLP ELFSPGMLVR CVVSSLGITD RGKKSVKLSL NPKNVNRVLS
       190        200        210        220        230        240
AEALKPGMLL TGTVSSLEDH GYLVDIGVDG TRAFLPLLKA QEYIRQKNKG AKLKVGQYLN
       250        260        270        280        290        300
CIVEKVKGNG GVVSLSVGHS EVSTAIATEQ QSWNLNNLLP GLVVKAQVQK VTPFGLTLNF
       310        320        330        340        350        360
LTFFTGVVDF MHLDPKKAGT YFSNQAVRAC ILCVHPRTRV VHLSLRPIFL QPGRPLTRLS
       370        380        390        400        410        420
CQNLGAVLDD VPVQGFFKKA GATFRLKDGV LAYARLSHLS DSKNVFNPEA FKPGNTHKCR
       430        440        450        460        470        480
IIDYSQMDEL ALLSLRTSII EAQYLRYHDI EPGAVVKGTV LTIKSYGMLV KVGEQMRGLV
       490        500        510        520        530        540
PPMHLADILM KNPEKKYHIG DEVKCRVLLC DPEAKKLMMT LKKTLIESKL PVITCYADAK
       550        560        570        580        590        600
PGLQTHGFII RVKDYGCIVK FYNNVQGLVP KHELSTEYIP DPERVFYTGQ VVKVVVLNCE
       610        620        630        640        650        660
PSKERMLLSF KLSSDPEPKK EPAGHSQKKG KAINIGQLVD VKVLEKTKDG LEVAVLPHNI
       670        680        690        700        710        720
RAFLPTSHLS DHVANGPLLH HWLQAGDILH RVLCLSQSEG RVLLCRKPAL VSTVEGGQDP
       730        740        750        760        770        780
KNFSEIHPGM LLIGFVKSIK DYGVFIQFPS GLSGLAPKAI MSDKFVTSTS DHFVEGQTVA
       790        800        810        820        830        840
AKVTNVDEEK QRMLLSLRLS DCGLGDLAIT SLLLLNQCLE ELQGVRSLMS NRDSVLIQTL
       850        860        870        880        890        900
AEMTPGMFLD LVVQEVLEDG SVVFSGGPVP DLVLKASRYH RAGQEVESGQ KKKVVILNVD
       910        920        930        940        950        960
LLKLEVHVSL HQDLVNRKAR KLRKGSEHQA IVQHLEKSFA IASLVETGHL AAFSLTSHLN
       970        980        990       1000       1010       1020
DTFRFDSEKL QVGQGVSLTL KTTEPGVTGL LLAVEGPAAK RTMRPTQKDS ETVDEDEEVD
      1030       1040       1050       1060       1070       1080
PALTVGTIKK HTLSIGDMVT GTVKSIKPTH VVVTLEDGII GCIHASHILD DVPEGTSPTT
      1090       1100       1110       1120       1130       1140
KLKVGKTVTA RVIGGRDMKT FKYLPISHPR FVRTIPELSV RPSELEDGHT ALNTHSVSPM
      1150       1160       1170       1180       1190       1200
EKIKQYQAGQ TVTCFLKKYN VVKKWLEVEI APDIRGRIPL LLTSLSFKVL KHPDKKFRVG
      1210       1220       1230       1240       1250       1260
QALRATVVGP DSSKTLLCLS LTGPHKLEEG EVAMGRVVKV TPNEGLTVSF PFGKIGTVSI
      1270       1280       1290       1300       1310       1320
FHMSDSYSET PLEDFVPQKV VRCYILSTAD NVLTLSLRSS RTNPETKSKV EDPEINSIQD
      1330       1340       1350       1360       1370       1380
IKEGQLLRGY VGSIQPHGVF FRLGPSVVGL ARYSHVSQHS PSKKALYNKH LPEGKLLTAR
      1390       1400       1410       1420       1430       1440
VLRLNHQKNL VELSFLPGDT GKPDVLSASL EGQLTKQEER KTEAEERDQK GEKKNQKRNE
      1450       1460       1470       1480       1490       1500
KKNQKGQEEV EMPSKEKQQP QKPQAQKRGG RECRESGSEQ ERVSKKPKKA GLSEEDDSLV
      1510       1520       1530       1540       1550       1560
DVYYREGKEE AEETNVLPKE KQTKPAEAPR LQLSSGFAWN VGLDSLTPAL PPLAESSDSE
      1570       1580       1590       1600       1610       1620
EDEKPHQATI KKSKKERELE KQKAEKELSR IEEALMDPGR QPESADDFDR LVLSSPNSSI
      1630       1640       1650       1660       1670       1680
LWLQYMAFHL QATEIEKARA VAERALKTIS FREEQEKLNV WVALLNLENM YGSQESLTKV
      1690       1700       1710       1720       1730       1740
FERAVQYNEP LKVFLHLADI YAKSEKFQEA GELYNRMLKR FRQEKAVWIK YGAFLLRRSQ
      1750       1760       1770       1780       1790       1800
AAASHRVLQR ALECLPSKEH VDVIAKFAQL EFQLGDAERA KAIFENTLST YPKRTDVWSV
      1810       1820       1830       1840       1850       1860
YIDMTIKHGS QKDVRDIFER VIHLSLAPKR MKFFFKRYLD YEKQHGTEKD VQAVKAKALE
      1870
YVEAKSSVLE D

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14690-2-unknown	MANLEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14690-2-Acetylation	ANLEES...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14690-2-Acetylation	ANLEES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14690-2-Acetylation	ANLEES...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q14690-2-Acetylation	ANLEES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14690-31-unknown	NLFDIS...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12262
Q14690-1407-unknown	SASLEG...	1407		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14495
Q14690-1498-unknown	SLVDVY...	1498		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12263
Q14690-1545-	SLTPAL...	1545			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SVEQDN	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12262
...KPDVLS	1406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14495
...SEEDDS	1497	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12263
...SVLED	1871	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	30	EQDN.\|.NLFD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	1406	DVLS.\|.SASL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	1497	EDDS.\|.SLVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)