Q15032: R3H domain-containing protein 1

General Information

Protein names	- R3H domain-containing protein 1
Gene names	R3HDM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15032

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of R3H domain-containing protein 1 - Isoform 3 of R3H domain-containing protein 1 - Isoform 4 of R3H domain-containing protein 1 - Isoform 2 of R3H domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
        70         80         90        100        110        120
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
       130        140        150        160        170        180
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
       190        200        210        220        230        240
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
       250        260        270        280        290        300
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
       310        320        330        340        350        360
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
       370        380        390        400        410        420
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
       430        440        450        460        470        480
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
       490        500        510        520        530        540
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
       550        560        570        580        590        600
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
       610        620        630        640        650        660
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
       670        680        690        700        710        720
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
       730        740        750        760        770        780
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
       790        800        810        820        830        840
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
       850        860        870        880        890        900
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
       910        920        930        940        950        960
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
       970        980        990       1000       1010       1020
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
      1030       1040       1050       1060       1070       1080
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
      1090
LRTSKKHYDF HILERASSQ         10         20         30         40         50         60
MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
        70         80         90        100        110        120
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
       130        140        150        160        170        180
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
       190        200        210        220        230        240
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
       250        260        270        280        290        300
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
       310        320        330        340        350        360
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
       370        380        390        400        410        420
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
       430        440        450        460        470        480
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
       490        500        510        520        530        540
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
       550        560        570        580        590        600
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
       610        620        630        640        650        660
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
       670        680        690        700        710        720
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
       730        740        750        760        770        780
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
       790        800        810        820        830        840
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
       850        860        870        880        890        900
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
       910        920        930        940        950        960
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
       970        980        990       1000       1010       1020
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
      1030       1040       1050       1060       1070       1080
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
      1090
LRTSKKHYDF HILERASSQ         10         20         30         40         50         60
MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
        70         80         90        100        110        120
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
       130        140        150        160        170        180
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
       190        200        210        220        230        240
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
       250        260        270        280        290        300
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
       310        320        330        340        350        360
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
       370        380        390        400        410        420
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
       430        440        450        460        470        480
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
       490        500        510        520        530        540
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
       550        560        570        580        590        600
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
       610        620        630        640        650        660
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
       670        680        690        700        710        720
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
       730        740        750        760        770        780
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
       790        800        810        820        830        840
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
       850        860        870        880        890        900
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
       910        920        930        940        950        960
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
       970        980        990       1000       1010       1020
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
      1030       1040       1050       1060       1070       1080
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
      1090
LRTSKKHYDF HILERASSQ         10         20         30         40         50         60
MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
        70         80         90        100        110        120
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
       130        140        150        160        170        180
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
       190        200        210        220        230        240
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
       250        260        270        280        290        300
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
       310        320        330        340        350        360
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
       370        380        390        400        410        420
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
       430        440        450        460        470        480
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
       490        500        510        520        530        540
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
       550        560        570        580        590        600
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
       610        620        630        640        650        660
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
       670        680        690        700        710        720
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
       730        740        750        760        770        780
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
       790        800        810        820        830        840
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
       850        860        870        880        890        900
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
       910        920        930        940        950        960
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
       970        980        990       1000       1010       1020
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
      1030       1040       1050       1060       1070       1080
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
      1090
LRTSKKHYDF HILERASSQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15032-1-unknown	MRMSDT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15032-1-unknown	MRMSDT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86794
Q15032-1-unknown	MRMSDT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86795
Q15032-302-unknown	SLCSQE...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12337
Q15032-302-unknown	SLCSQE...	302	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148284
Q15032-302-unknown	SLCSQE...	302	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148733
Q15032-302-unknown	SLCSQE...	302	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149918
Q15032-500-	GSPVVY...	500		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15032-500-unknown	GSPVVY...	500		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15032-500-unknown	GSPVVY...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161959
Q15032-500-unknown	GSPVVY...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161957
Q15032-500-unknown	GSPVVY...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161958
Q15032-785-	SSSVGY...	785		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15032-785-unknown	SSSVGY...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174223
Q15032-785-unknown	SSSVGY...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174221
Q15032-785-unknown	SSSVGY...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174222

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIFSQD	300	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405668
...RIFSQD	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12337
...LPPGQP	610	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387750
...RASSQ	1099	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RASSQ	1099	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82412
...RASSQ	1099	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82414
...RASSQ	1099	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82413

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	301	SQDS.\|.SLCS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)