Q15057: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

General Information

Protein names	- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 - Centaurin-beta-2 - Cnt-b2
Gene names	ACAP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15057

4 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK AFCVANKQFM
        70         80         90        100        110        120
NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ TQRSIKAQLQ NFVKEDLRKF
       130        140        150        160        170        180
KDAKKQFEKV SEEKENALVK NAQVQRNKQH EVEEATNILT ATRKCFRHIA LDYVLQINVL
       190        200        210        220        230        240
QSKRRSEILK SMLSFMYAHL AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ
       250        260        270        280        290        300
KHSTIQQKDF SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK
       310        320        330        340        350        360
KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ AWIKAVQTSI
       370        380        390        400        410        420
ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES ALQRVQCIPG NASCCDCGLA
       430        440        450        460        470        480
DPRWASINLG ITLCIECSGI HRSLGVHFSK VRSLTLDTWE PELLKLMCEL GNDVINRVYE
       490        500        510        520        530        540
ANVEKMGIKK PQPGQRQEKE AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS
       550        560        570        580        590        600
ISKFGPGDQV RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD
       610        620        630        640        650        660
SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL GGSLVTCEFL
       670        680        690        700        710        720
LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ HATDEEGKDP LSIAVEAANA
       730        740        750        760        770
DIVTLLRLAR MNEEMRESEG LYGQPGDETY QDIFRDFSQM ASNNPEKLNR FQQDSQKF

Isoforms

Sequence View

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Directness:

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Evidence Codes:

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Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15057-1-unknown	MKMTVD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15057-45-unknown	MIDTGK...	45	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411336
Q15057-584-unknown	SLYEPE...	584	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12346
Q15057-584-	SLYEPE...	584		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...INFHTI	95	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411336
...AFFHQG	205	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399855
...KSSPST	381	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413388
...TVSANS	583	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12346
...ADVNWA	634	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412338
...DSQKF	778	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DSQKF	778		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSQKF	778		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DSQKF	778		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DSQKF	778		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	583	SANS.\|.SLYE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)