Q15276: Rab GTPase-binding effector protein 1

General Information

Protein names	- Rab GTPase-binding effector protein 1 - Rabaptin-4 - Rabaptin-5 - Rabaptin-5alpha - Renal carcinoma antigen NY-REN-17
Gene names	RABEP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15276

13 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQPGPASQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ
        70         80         90        100        110        120
NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAV
       130        140        150        160        170        180
MKETVRDYEH QFHLRLEQER TQWAQYRESA EREIADLRRR LSEGQEEENL ENEMKKAQED
       190        200        210        220        230        240
AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV
       250        260        270        280        290        300
LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR
       310        320        330        340        350        360
MEIVLTSEQL RQVEELKKKD QEDDEQQRLN KRKDHKKADV EEEIKIPVVC ALTQEESSAQ
       370        380        390        400        410        420
LSNEEEHLDS TRGSVHSLDA GLLLPSGDPF SKSDNDMFKD GLRRAQSTDS LGTSGSLQSK
       430        440        450        460        470        480
ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTASLGSL QMPSGFMLTK DQERAIKAMT
       490        500        510        520        530        540
PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE
       550        560        570        580        590        600
KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKDKQE LEDFIKQSSE DSSHQISALV
       610        620        630        640        650        660
LRAQASEILL EELQQGLSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV
       670        680        690        700        710        720
SLQQAEDFIL PDTTEALREL VLKYREDIIN VRTAADHVEE KLKAEILFLK EQIQAEQCLK
       730        740        750        760        770        780
ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEIKISLE
       790        800        810        820        830        840
EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS
       850        860
LERIRAILND TKLTDINQLP ET

Isoforms

- Isoform 2 of Rab GTPase-binding effector protein 1

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15276-1-unknown	MAQPGP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86859
Q15276-2-unknown	MAQPGP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15276-2-Acetylation	AQPGPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15276-2-Acetylation	AQPGPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15276-2-Acetylation	AQPGPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15276-2-Acetylation	AQPGPA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15276-2-Acetylation	AQPGPA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110619
Q15276-351-unknown	ALTQEE...	351		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171747
Q15276-351-	ALTQEE...	351			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15276-380-unknown	AGLLLP...	380		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2214
Q15276-380-unknown	AGLLLP...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151621
Q15276-439-unknown	FGPLVG...	439		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2216
Q15276-439-unknown	FGPLVG...	439		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152622
Q15276-459-	SLQMPS...	459			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15276-459-unknown	SLQMPS...	459		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167533
Q15276-492-unknown	SVTQGM...	492		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167535
Q15276-492-	SVTQGM...	492			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15276-492-	SVTQGM...	492			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15276-492-	SVTQGM...	492			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15276-690-unknown	NVRTAA...	690		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172795
Q15276-690-	NVRTAA...	690			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VHSLDA	379	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2214
...VHSLDA	379	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135025
...LDESDF	438	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2216
...LDESDF	438	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136039
...QLPET	862	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QLPET	862	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82477
...QLPET	862		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QLPET	862		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QLPET	862		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QLPET	862		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	379	SLDA.\|.AGLL	inferred from experiment	unknown	MEROPS	Woodman P	Swanton E et al.:Human rabaptin-5 is selectively... (C14.003)	10608812,
CASP3_HUMAN	438	ESDF.\|.FGPL	inferred from experiment	unknown	MEROPS	Woodman PG	Cosulich SC et al.:Cleavage of rabaptin-5 blocks e... (C14.003)	9321397,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)