Q15428: Splicing factor 3A subunit 2

General Information

Protein names	- Splicing factor 3A subunit 2 - SF3a66 {ECO:0000303\|PubMed:11533230, ECO:0000303\|PubMed:21349847} - Spliceosome-associated protein 62 - SAP 62
Gene names	SF3A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15428

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL
        70         80         90        100        110        120
TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT
       130        140        150        160        170        180
KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA
       190        200        210        220        230        240
FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG
       250        260        270        280        290        300
LPPRPPLPES LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG
       310        320        330        340        350        360
VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV HPPAPGVHPP
       370        380        390        400        410        420
APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM HPQAPGVHPQ PPGVHPSAPG
       430        440        450        460
VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP SEGPGNIPPP PPTN

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15428-1-Acetylation	MDFQHR...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15428-11-unknown	TGSGGV...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10317
Q15428-11-unknown	TGSGGV...	11		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15428-11-unknown	TGSGGV...	11		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q15428-89-	EAKEAP...	89			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15428-171-	MAAEPY...	171			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15428-172-	AAEPYE...	172			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RPGGKT	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10317
...SLLFQI	135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466634
...PPPTN	464	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	10	GGKT.\|.TGSG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)