Q16270: Insulin-like growth factor-binding protein 7

General Information

Protein names	- Insulin-like growth factor-binding protein 7 - IBP-7 - IGF-binding protein 7 - IGFBP-7 - IGFBP-rP1 - MAC25 protein - PGI2-stimulating factor - Prostacyclin-stimulating factor - Tumor-derived adhesion factor - TAF
Gene names	IGFBP7
Organism	Homo sapiens
Protease Family
Protease ID	I43.001
Chromosome location
UniProt ID	Q16270

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC
        70         80         90        100        110        120
PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC
       130        140        150        160        170        180
GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS
       190        200        210        220        230        240
CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK
       250        260        270        280
EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

Isoforms

- Isoform 2 of Insulin-like growth factor-binding protein 7

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16270-1-unknown	MERPSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77460
Q16270-27-unknown	SSSDTC...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16270-27-unknown	SSSDTC...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114229
Q16270-98-unknown	AGAAAG...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31616
Q16270-98-unknown	AGAAAG...	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142289
Q16270-100-unknown	AAAGGP...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17992
Q16270-100-unknown	AAAGGP...	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142400

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRKGKA	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31616
...RRKGKA	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125479
...KGKAGA	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17992
...KGKAGA	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125592
...EGAEL	282	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ST14_HUMAN	97	KGKA.\|.AGAA	inferred from experiment	unknown	MEROPS	Miyazaki K	Ahmed S et al.:Identification of membrane-boun... (S01.302)	16420484,
MEP1A_HUMAN	99	KAGA.\|.AAAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)