Q16836: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Protein names | - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial - HCDH - 1.1.1.35 - Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase - Short-chain 3-hydroxyacyl-CoA dehydrogenase |
---|---|
Gene names | HADH |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q16836 |
14
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE
70 80 90 100 110 120
DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI
130 140 150 160 170 180
VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL
190 200 210 220 230 240
VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS
250 260 270 280 290 300
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN
310
KFGKKTGEGF YKYK
Isoforms
- Isoform 2 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial - Isoform 3 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialSequence View
10 20 30 40 50 60
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE
70 80 90 100 110 120
DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI
130 140 150 160 170 180
VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL
190 200 210 220 230 240
VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS
250 260 270 280 290 300
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN
310
KFGKKTGEGF YKYK
10 20 30 40 50 60
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE
70 80 90 100 110 120
DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI
130 140 150 160 170 180
VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL
190 200 210 220 230 240
VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS
250 260 270 280 290 300
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN
310
KFGKKTGEGF YKYK
Protein Neighborhood
Domains & Features
14 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q16836-1-unknown | MAFVTR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt76781 | |||
Q16836-1-unknown | MAFVTR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt109006 | |||
Q16836-11-unknown | SVSSSS... | 11 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177779 | |||
Q16836-11-unknown | SVSSSS... | 11 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177780 | |||
Q16836-11- | SVSSSS... | 11 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | RMPI_untreated | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q16836-12- | VSSSST... | 12 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q16836-12-unknown | VSSSST... | 12 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q16836-12-unknown | VSSSST... | 12 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q16836-12-unknown | VSSSST... | 12 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159698 | |||
Q16836-12-unknown | VSSSST... | 12 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159699 | |||
Q16836-13-unknown | SSSSTA... | 13 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q16836-13-unknown | SSSSTA... | 13 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q16836-13-unknown | SSSSTA... | 13 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111762 | |||
Q16836-13-unknown | SSSSTA... | 13 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111763 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q16836-13- | SSSSTA... | 13 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q16836-14-unknown | SSSTAS... | 14 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165079 | |||
Q16836-14-unknown | SSSTAS... | 14 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165080 | |||
Q16836-14- | SSSTAS... | 14 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q16836-14- | SSSTAS... | 14 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q16836-155-unknown | SIANAT... | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173691 | |||
Q16836-155-unknown | SIANAT... | 155 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173692 | |||
Q16836-155- | SIANAT... | 155 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q16836-167-unknown | AGLHFF... | 167 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175332 | |||
Q16836-167-unknown | AGLHFF... | 167 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175333 | |||
Q16836-167- | AGLHFF... | 167 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q16836-276-unknown | GWHEMD... | 276 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7887 | |||
Q16836-276-unknown | GWHEMD... | 276 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149691 | |||
Q16836-276-unknown | GWHEMD... | 276 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150989 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KFIVDG | 275 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7887 | |||
...KFIVDG | 275 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133079 | |||
...KFIVDG | 275 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134392 | |||
...FYKYK | 314 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...FYKYK | 314 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt72399 | |||
...FYKYK | 314 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt72398 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATS_HUMAN | 275 | IVDG.|.GWHE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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