Q27J81: Inverted formin-2

General Information

Protein names	- Inverted formin-2 - HBEBP2-binding protein C
Gene names	INF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q27J81

9 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Inverted formin-2 - Isoform 3 of Inverted formin-2

Sequence View

        10         20         30         40         50         60
MSVKEGAQRK WAALKEKLGP QDSDPTEANL ESADPELCIR LLQMPSVVNY SGLRKRLEGS
        70         80         90        100        110        120
DGGWMVQFLE QSGLDLLLEA LARLSGRGVA RISDALLQLT CVSCVRAVMN SRQGIEYILS
       130        140        150        160        170        180
NQGYVRQLSQ ALDTSNVMVK KQVFELLAAL CIYSPEGHVL TLDALDHYKT VCSQQYRFSI
       190        200        210        220        230        240
VMNELSGSDN VPYVVTLLSV INAVILGPED LRARTQLRNE FIGLQLLDVL ARLRDLEDAD
       250        260        270        280        290        300
LLIQLEAFEE AKAEDEEELL RVSGGVDMSS HQEVFASLFH KVSCSPVSAQ LLSVLQGLLH
       310        320        330        340        350        360
LEPTLRSSQL LWEALESLVN RAVLLASDAQ ECTLEEVVER LLSVKGRPRP SPLVKAHKSV
       370        380        390        400        410        420
QANLDQSQRG SSPQNTTTPK PSVEGQQPAA AAACEPVDHA QSESILKVSQ PRALEQQAST
       430        440        450        460        470        480
PPPPPPPPLL PGSSAEPPPP PPPPPLPSVG AKALPTAPPP PPLPGLGAMA PPAPPLPPPL
       490        500        510        520        530        540
PGSCEFLPPP PPPLPGLGCP PPPPPLLPGM GWGPPPPPPP LLPCTCSPPV AGGMEEVIVA
       550        560        570        580        590        600
QVDHGLGSAW VPSHRRVNPP TLRMKKLNWQ KLPSNVAREH NSMWASLSSP DAEAVEPDFS
       610        620        630        640        650        660
SIERLFSFPA AKPKEPTMVA PRARKEPKEI TFLDAKKSLN LNIFLKQFKC SNEEVAAMIR
       670        680        690        700        710        720
AGDTTKFDVE VLKQLLKLLP EKHEIENLRA FTEERAKLAS ADHFYLLLLA IPCYQLRIEC
       730        740        750        760        770        780
MLLCEGAAAV LDMVRPKAQL VLAACESLLT SRQLPIFCQL ILRIGNFLNY GSHTGDADGF
       790        800        810        820        830        840
KISTLLKLTE TKSQQNRVTL LHHVLEEAEK SHPDLLQLPR DLEQPSQAAG INLEIIRSEA
       850        860        870        880        890        900
SSNLKKLLET ERKVSASVAE VQEQYTERLQ ASISAFRALD ELFEAIEQKQ RELADYLCED
       910        920        930        940        950        960
AQQLSLEDTF STMKAFRDLF LRALKENKDR KEQAAKAERR KQQLAEEEAR RPRGEDGKPV
       970        980        990       1000       1010       1020
RKGPGKQEEV CVIDALLADI RKGFQLRKTA RGRGDTDGGS KAASMDPPRA TEPVATSNPA
      1030       1040       1050       1060       1070       1080
GDPVGSTRCP ASEPGLDATT ASESRGWDLV DAVTPGPQPT LEQLEEGGPR PLERRSSWYV
      1090       1100       1110       1120       1130       1140
DASDVLTTED PQCPQPLEGA WPVTLGDAQA LKPLKFSSNQ PPAAGSSRQD AKDPTSLLGV
      1150       1160       1170       1180       1190       1200
LQAEADSTSE GLEDAVHSRG ARPPAAGPGG DEDEDEEDTA PESALDTSLD KSFSEDAVTD
      1210       1220       1230       1240
SSGSGTLPRA RGRASKGTGK RRKKRPSRSQ EEVPPDSDDN KTKKLCVIQ         10         20         30         40         50         60
MSVKEGAQRK WAALKEKLGP QDSDPTEANL ESADPELCIR LLQMPSVVNY SGLRKRLEGS
        70         80         90        100        110        120
DGGWMVQFLE QSGLDLLLEA LARLSGRGVA RISDALLQLT CVSCVRAVMN SRQGIEYILS
       130        140        150        160        170        180
NQGYVRQLSQ ALDTSNVMVK KQVFELLAAL CIYSPEGHVL TLDALDHYKT VCSQQYRFSI
       190        200        210        220        230        240
VMNELSGSDN VPYVVTLLSV INAVILGPED LRARTQLRNE FIGLQLLDVL ARLRDLEDAD
       250        260        270        280        290        300
LLIQLEAFEE AKAEDEEELL RVSGGVDMSS HQEVFASLFH KVSCSPVSAQ LLSVLQGLLH
       310        320        330        340        350        360
LEPTLRSSQL LWEALESLVN RAVLLASDAQ ECTLEEVVER LLSVKGRPRP SPLVKAHKSV
       370        380        390        400        410        420
QANLDQSQRG SSPQNTTTPK PSVEGQQPAA AAACEPVDHA QSESILKVSQ PRALEQQAST
       430        440        450        460        470        480
PPPPPPPPLL PGSSAEPPPP PPPPPLPSVG AKALPTAPPP PPLPGLGAMA PPAPPLPPPL
       490        500        510        520        530        540
PGSCEFLPPP PPPLPGLGCP PPPPPLLPGM GWGPPPPPPP LLPCTCSPPV AGGMEEVIVA
       550        560        570        580        590        600
QVDHGLGSAW VPSHRRVNPP TLRMKKLNWQ KLPSNVAREH NSMWASLSSP DAEAVEPDFS
       610        620        630        640        650        660
SIERLFSFPA AKPKEPTMVA PRARKEPKEI TFLDAKKSLN LNIFLKQFKC SNEEVAAMIR
       670        680        690        700        710        720
AGDTTKFDVE VLKQLLKLLP EKHEIENLRA FTEERAKLAS ADHFYLLLLA IPCYQLRIEC
       730        740        750        760        770        780
MLLCEGAAAV LDMVRPKAQL VLAACESLLT SRQLPIFCQL ILRIGNFLNY GSHTGDADGF
       790        800        810        820        830        840
KISTLLKLTE TKSQQNRVTL LHHVLEEAEK SHPDLLQLPR DLEQPSQAAG INLEIIRSEA
       850        860        870        880        890        900
SSNLKKLLET ERKVSASVAE VQEQYTERLQ ASISAFRALD ELFEAIEQKQ RELADYLCED
       910        920        930        940        950        960
AQQLSLEDTF STMKAFRDLF LRALKENKDR KEQAAKAERR KQQLAEEEAR RPRGEDGKPV
       970        980        990       1000       1010       1020
RKGPGKQEEV CVIDALLADI RKGFQLRKTA RGRGDTDGGS KAASMDPPRA TEPVATSNPA
      1030       1040       1050       1060       1070       1080
GDPVGSTRCP ASEPGLDATT ASESRGWDLV DAVTPGPQPT LEQLEEGGPR PLERRSSWYV
      1090       1100       1110       1120       1130       1140
DASDVLTTED PQCPQPLEGA WPVTLGDAQA LKPLKFSSNQ PPAAGSSRQD AKDPTSLLGV
      1150       1160       1170       1180       1190       1200
LQAEADSTSE GLEDAVHSRG ARPPAAGPGG DEDEDEEDTA PESALDTSLD KSFSEDAVTD
      1210       1220       1230       1240
SSGSGTLPRA RGRASKGTGK RRKKRPSRSQ EEVPPDSDDN KTKKLCVIQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q27J81-1-unknown	MSVKEG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77888
Q27J81-1-unknown	MSVKEG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77889
Q27J81-2-unknown	MSVKEG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q27J81-2-Acetylation	SVKEGA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q27J81-2-Acetylation	SVKEGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q27J81-2-Acetylation	SVKEGA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q27J81-2-Acetylation	SVKEGA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111422
Q27J81-2-Acetylation	SVKEGA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111423
Q27J81-607-	SFPAAK...	607			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q27J81-607-unknown	SFPAAK...	607			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q27J81-607-unknown	SFPAAK...	607		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159820
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q27J81-1052-	AVTPGP...	1052			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q27J81-1052-unknown	AVTPGP...	1052			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q27J81-1052-unknown	AVTPGP...	1052		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161718
Q27J81-1147-unknown	STSEGL...	1147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1307
Q27J81-1147-unknown	STSEGL...	1147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157497
Q27J81-1147-	STSEGL...	1147			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LARLRD	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73507
...LARLRD	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92057
...QAEADS	1146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1307
...QAEADS	1146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140995
...LCVIQ	1249	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	1146	EADS.\|.STSE	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)