Q2T9J0: Peroxisomal leader peptide-processing protease

General Information

Protein names	- Peroxisomal leader peptide-processing protease - 3.4.21.- - Trypsin domain-containing protein 1 - Peroxisomal leader peptide-processing protease, 15 kDa form - Peroxisomal leader peptide-processing protease, 45 kDa form
Gene names	TYSND1
Organism	Homo sapiens
Protease Family
Protease ID	S01.286
Chromosome location
UniProt ID	Q2T9J0

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRRQWGSAMR AAEQAGCMVS ASRAGQPEAG PWSCSGVILS RSPGLVLCHG GIFVPFLRAG
        70         80         90        100        110        120
SEVLTAAGAV FLPGDSCRDD LRLHVQWAPT AAGPGGGAER GRPGLCTPQC ASLEPGPPAP
       130        140        150        160        170        180
SRGRPLQPRL PAELLLLLSC PAFWAHFARL FGDEAAEQWR FSSAARDDEV SEDEEADQLR
       190        200        210        220        230        240
ALGWFALLGV RLGQEEVEEE RGPAMAVSPL GAVPKGAPLL VCGSPFGAFC PDIFLNTLSC
       250        260        270        280        290        300
GVLSNVAGPL LLTDARCLPG TEGGGVFTAR PAGALVALVV APLCWKAGEW VGFTLLCAAA
       310        320        330        340        350        360
PLFRAARDAL HRLPHSTAAL AALLPPEVGV PWGLPLRDSG PLWAAAAVLV ECGTVWGSGV
       370        380        390        400        410        420
AVAPRLVVTC RHVSPREAAR VLVRSTTPKS VAIWGRVVFA TQETCPYDIA VVSLEEDLDD
       430        440        450        460        470        480
VPIPVPAEHF HEGEAVSVVG FGVFGQSCGP SVTSGILSAV VQVNGTPVML QTTCAVHSGS
       490        500        510        520        530        540
SGGPLFSNHS GNLLGIITSN TRDNNTGATY PHLNFSIPIT VLQPALQQYS QTQDLGGLRE
       550        560
LDRAAEPVRV VWRLQRPLAE APRSKL

Isoforms

- Isoform 2 of Peroxisomal leader peptide-processing protease

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q2T9J0-1-unknown	MRRQWG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2T9J0-1-unknown	MRRQWG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93498
Q2T9J0-111-	ASLEPG...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q2T9J0-111-	ASLEPG...	111		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q2T9J0-111-	ASLEPG...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q2T9J0-111-	ASLEPG...	111		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q2T9J0-111-	ASLEPG...	111		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q2T9J0-111-unknown	ASLEPG...	111	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2T9J0-111-unknown	ASLEPG...	111		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q2T9J0-111-unknown	ASLEPG...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115888

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CTPQCA	110	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CTPQCA	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91529
...PRSKL	566	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)