Q2VPK5: Cytoplasmic tRNA 2-thiolation protein 2 {ECO:0000255|HAMAP-Rule:MF_03054}

General Information

Protein names	- Cytoplasmic tRNA 2-thiolation protein 2 {ECO:0000255\|HAMAP-Rule:MF_03054} - Cytosolic thiouridylase subunit 2
Gene names	CTU2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q2VPK5

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cytoplasmic tRNA 2-thiolation protein 2 - Isoform 3 of Cytoplasmic tRNA 2-thiolation protein 2

Sequence View

        10         20         30         40         50         60
MCQVGEDYGE PAPEEPPPAP RPSREQKCVK CKEAQPVVVI RAGDAFCRDC FKAFYVHKFR
        70         80         90        100        110        120
AMLGKNRLIF PGEKVLLAWS GGPSSSSMVW QVLEGLSQDS AKRLRFVAGV IFVDEGAACG
       130        140        150        160        170        180
QSLEERSKTL AEVKPILQAT GFPWHVVALE EVFSLPPSVL WCSAQELVGS EGAYKAAVDS
       190        200        210        220        230        240
FLQQQHVLGA GGGPGPTQGE EQPPQPPLDP QNLARPPAPA QTEALSQLFC SVRTLTAKEE
       250        260        270        280        290        300
LLQTLRTHLI LHMARAHGYS KVMTGDSCTR LAIKLMTNLA LGRGAFLAWD TGFSDERHGD
       310        320        330        340        350        360
VVVVRPMRDH TLKEVAFYNR LFSVPSVFTP AVDTKAPEKA SIHRLMEAFI LRLQTQFPST
       370        380        390        400        410        420
VSTVYRTSEK LVKGPRDGPA AGDSGPRCLL CMCALDVDAA DSATAFGAQT SSRLSQMQSP
       430        440        450        460        470        480
IPLTETRTPP GPCCSPGVGW AQRCGQGACR REDPQACIEE QLCYSCRVNM KDLPSLDPLP
       490        500        510
PYILAEAQLR TQRAWGLQEI RDCLIEDSDD EAGQS         10         20         30         40         50         60
MCQVGEDYGE PAPEEPPPAP RPSREQKCVK CKEAQPVVVI RAGDAFCRDC FKAFYVHKFR
        70         80         90        100        110        120
AMLGKNRLIF PGEKVLLAWS GGPSSSSMVW QVLEGLSQDS AKRLRFVAGV IFVDEGAACG
       130        140        150        160        170        180
QSLEERSKTL AEVKPILQAT GFPWHVVALE EVFSLPPSVL WCSAQELVGS EGAYKAAVDS
       190        200        210        220        230        240
FLQQQHVLGA GGGPGPTQGE EQPPQPPLDP QNLARPPAPA QTEALSQLFC SVRTLTAKEE
       250        260        270        280        290        300
LLQTLRTHLI LHMARAHGYS KVMTGDSCTR LAIKLMTNLA LGRGAFLAWD TGFSDERHGD
       310        320        330        340        350        360
VVVVRPMRDH TLKEVAFYNR LFSVPSVFTP AVDTKAPEKA SIHRLMEAFI LRLQTQFPST
       370        380        390        400        410        420
VSTVYRTSEK LVKGPRDGPA AGDSGPRCLL CMCALDVDAA DSATAFGAQT SSRLSQMQSP
       430        440        450        460        470        480
IPLTETRTPP GPCCSPGVGW AQRCGQGACR REDPQACIEE QLCYSCRVNM KDLPSLDPLP
       490        500        510
PYILAEAQLR TQRAWGLQEI RDCLIEDSDD EAGQS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q2VPK5-1-unknown	MCQVGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72128
Q2VPK5-2-unknown	MCQVGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2VPK5-2-Acetylation	CQVGED...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2VPK5-2-Acetylation	CQVGED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q2VPK5-2-Acetylation	CQVGED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q2VPK5-2-Acetylation	CQVGED...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111657
Q2VPK5-88-unknown	MVWQVL...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72127
Q2VPK5-88-unknown	MVWQVL...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106545
Q2VPK5-399-unknown	AADSAT...	399		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12412
Q2VPK5-399-unknown	AADSAT...	399		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150160
Q2VPK5-399-unknown	AADSAT...	399		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151994
Q2VPK5-402-unknown	SATAFG...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172728
Q2VPK5-402-unknown	SATAFG...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172727
Q2VPK5-402-	SATAFG...	402			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ALDVDA	398	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12412
...ALDVDA	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133553
...ALDVDA	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135402
...EAGQS	515	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EAGQS	515	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67745
...EAGQS	515		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	398	DVDA.\|.AADS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)