Q3T8J9: GON-4-like protein
| Protein names | - GON-4-like protein - GON-4 homolog |
|---|---|
| Gene names | GON4L |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q3T8J9 |
5
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD PSHGRVAGFE
70 80 90 100 110 120
VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS QGITLPSLES FHPLNIHIGK
130 140 150 160 170 180
GKLHATGSKR GKKMTLRPGP VTQEDRCDHL TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP
190 200 210 220 230 240
SLPSGSQSAK PVSQPRKSTQ PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES
250 260 270 280 290 300
EKRRKKKKGT KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
310 320 330 340 350 360
NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK ANEIKPPQFV
370 380 390 400 410 420
DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS PRGAKKSRLR QSSEMTETDE
430 440 450 460 470 480
ESGILSEAEK VTTPAIRHIS AEVVPMGPPP PPKPKQTRDS TFMEKLHAVD EELASSPVCM
490 500 510 520 530 540
DSFQPMDDSL IAFRTRSKMP LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL
550 560 570 580 590 600
MNDDVGNEDE ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
610 620 630 640 650 660
MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL FEQLKMKKSS
670 680 690 700 710 720
AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAT
730 740 750 760 770 780
TTRIFLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV
790 800 810 820 830 840
KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH
850 860 870 880 890 900
FEGTEFPNPL ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
910 920 930 940 950 960
QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDRSLEKDN
970 980 990 1000 1010 1020
LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK
1030 1040 1050 1060 1070 1080
TPARSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAVPPEAR
1090 1100 1110 1120 1130 1140
TSFPLSESQT LLSSAPVPKV MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP
1150 1160 1170 1180 1190 1200
ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
1210 1220 1230 1240 1250 1260
SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT
1270 1280 1290 1300 1310 1320
VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ ALEPLPQGIQ ESLNNPTPGD
1330 1340 1350 1360 1370 1380
LEEIVKMEPE EAREEISGSP ERDICDDIKV EHAVELDTGA PSEELSSAGE VTKQTVLQKE
1390 1400 1410 1420 1430 1440
EERSQPTKTP SSSQEPPDEG TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ
1450 1460 1470 1480 1490 1500
SVGTPVGPET GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
1510 1520 1530 1540 1550 1560
ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG DSAEKPPTFA
1570 1580 1590 1600 1610 1620
SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR ASKDTSKLLL LYDEDILERD
1630 1640 1650 1660 1670 1680
PLREQKDLAF AQAYLTRVRE ALQHIPGKYE DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ
1690 1700 1710 1720 1730 1740
DWPQLLKDFA AFLLPEQALA CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG
1750 1760 1770 1780 1790 1800
CADCLPQEIT ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
1810 1820 1830 1840 1850 1860
DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC ACSCHEGGPD
1870 1880 1890 1900 1910 1920
SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE ASPMPGAKEA GQGKDMMEEE
1930 1940 1950 1960 1970 1980
APEERESTEA TQSRTVRTTR KGEMPVSAGL AVGSTLPSPR EVTVTERLLL DGPPPHSPET
1990 2000 2010 2020 2030 2040
PQFPPTTGAV LYTVKRNQVG PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK
2050 2060 2070 2080 2090 2100
LPGTVEPPAS FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
2110 2120 2130 2140 2150 2160
IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG EKVVLWTREA
2170 2180 2190 2200 2210 2220
DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL MQLFHTACEA SSEDEDDATS
2230 2240
TSNADQLSDH GDLLSEEELD E
Isoforms
- Isoform 2 of GON-4-like protein - Isoform 3 of GON-4-like proteinSequence View
10 20 30 40 50 60
MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD PSHGRVAGFE
70 80 90 100 110 120
VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS QGITLPSLES FHPLNIHIGK
130 140 150 160 170 180
GKLHATGSKR GKKMTLRPGP VTQEDRCDHL TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP
190 200 210 220 230 240
SLPSGSQSAK PVSQPRKSTQ PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES
250 260 270 280 290 300
EKRRKKKKGT KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
310 320 330 340 350 360
NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK ANEIKPPQFV
370 380 390 400 410 420
DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS PRGAKKSRLR QSSEMTETDE
430 440 450 460 470 480
ESGILSEAEK VTTPAIRHIS AEVVPMGPPP PPKPKQTRDS TFMEKLHAVD EELASSPVCM
490 500 510 520 530 540
DSFQPMDDSL IAFRTRSKMP LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL
550 560 570 580 590 600
MNDDVGNEDE ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
610 620 630 640 650 660
MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL FEQLKMKKSS
670 680 690 700 710 720
AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAT
730 740 750 760 770 780
TTRIFLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV
790 800 810 820 830 840
KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH
850 860 870 880 890 900
FEGTEFPNPL ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
910 920 930 940 950 960
QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDRSLEKDN
970 980 990 1000 1010 1020
LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK
1030 1040 1050 1060 1070 1080
TPARSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAVPPEAR
1090 1100 1110 1120 1130 1140
TSFPLSESQT LLSSAPVPKV MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP
1150 1160 1170 1180 1190 1200
ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
1210 1220 1230 1240 1250 1260
SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT
1270 1280 1290 1300 1310 1320
VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ ALEPLPQGIQ ESLNNPTPGD
1330 1340 1350 1360 1370 1380
LEEIVKMEPE EAREEISGSP ERDICDDIKV EHAVELDTGA PSEELSSAGE VTKQTVLQKE
1390 1400 1410 1420 1430 1440
EERSQPTKTP SSSQEPPDEG TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ
1450 1460 1470 1480 1490 1500
SVGTPVGPET GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
1510 1520 1530 1540 1550 1560
ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG DSAEKPPTFA
1570 1580 1590 1600 1610 1620
SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR ASKDTSKLLL LYDEDILERD
1630 1640 1650 1660 1670 1680
PLREQKDLAF AQAYLTRVRE ALQHIPGKYE DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ
1690 1700 1710 1720 1730 1740
DWPQLLKDFA AFLLPEQALA CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG
1750 1760 1770 1780 1790 1800
CADCLPQEIT ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
1810 1820 1830 1840 1850 1860
DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC ACSCHEGGPD
1870 1880 1890 1900 1910 1920
SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE ASPMPGAKEA GQGKDMMEEE
1930 1940 1950 1960 1970 1980
APEERESTEA TQSRTVRTTR KGEMPVSAGL AVGSTLPSPR EVTVTERLLL DGPPPHSPET
1990 2000 2010 2020 2030 2040
PQFPPTTGAV LYTVKRNQVG PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK
2050 2060 2070 2080 2090 2100
LPGTVEPPAS FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
2110 2120 2130 2140 2150 2160
IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG EKVVLWTREA
2170 2180 2190 2200 2210 2220
DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL MQLFHTACEA SSEDEDDATS
2230 2240
TSNADQLSDH GDLLSEEELD E
10 20 30 40 50 60
MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD PSHGRVAGFE
70 80 90 100 110 120
VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS QGITLPSLES FHPLNIHIGK
130 140 150 160 170 180
GKLHATGSKR GKKMTLRPGP VTQEDRCDHL TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP
190 200 210 220 230 240
SLPSGSQSAK PVSQPRKSTQ PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES
250 260 270 280 290 300
EKRRKKKKGT KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
310 320 330 340 350 360
NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK ANEIKPPQFV
370 380 390 400 410 420
DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS PRGAKKSRLR QSSEMTETDE
430 440 450 460 470 480
ESGILSEAEK VTTPAIRHIS AEVVPMGPPP PPKPKQTRDS TFMEKLHAVD EELASSPVCM
490 500 510 520 530 540
DSFQPMDDSL IAFRTRSKMP LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL
550 560 570 580 590 600
MNDDVGNEDE ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
610 620 630 640 650 660
MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL FEQLKMKKSS
670 680 690 700 710 720
AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAT
730 740 750 760 770 780
TTRIFLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV
790 800 810 820 830 840
KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH
850 860 870 880 890 900
FEGTEFPNPL ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
910 920 930 940 950 960
QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDRSLEKDN
970 980 990 1000 1010 1020
LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK
1030 1040 1050 1060 1070 1080
TPARSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAVPPEAR
1090 1100 1110 1120 1130 1140
TSFPLSESQT LLSSAPVPKV MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP
1150 1160 1170 1180 1190 1200
ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
1210 1220 1230 1240 1250 1260
SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT
1270 1280 1290 1300 1310 1320
VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ ALEPLPQGIQ ESLNNPTPGD
1330 1340 1350 1360 1370 1380
LEEIVKMEPE EAREEISGSP ERDICDDIKV EHAVELDTGA PSEELSSAGE VTKQTVLQKE
1390 1400 1410 1420 1430 1440
EERSQPTKTP SSSQEPPDEG TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ
1450 1460 1470 1480 1490 1500
SVGTPVGPET GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
1510 1520 1530 1540 1550 1560
ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG DSAEKPPTFA
1570 1580 1590 1600 1610 1620
SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR ASKDTSKLLL LYDEDILERD
1630 1640 1650 1660 1670 1680
PLREQKDLAF AQAYLTRVRE ALQHIPGKYE DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ
1690 1700 1710 1720 1730 1740
DWPQLLKDFA AFLLPEQALA CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG
1750 1760 1770 1780 1790 1800
CADCLPQEIT ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
1810 1820 1830 1840 1850 1860
DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC ACSCHEGGPD
1870 1880 1890 1900 1910 1920
SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE ASPMPGAKEA GQGKDMMEEE
1930 1940 1950 1960 1970 1980
APEERESTEA TQSRTVRTTR KGEMPVSAGL AVGSTLPSPR EVTVTERLLL DGPPPHSPET
1990 2000 2010 2020 2030 2040
PQFPPTTGAV LYTVKRNQVG PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK
2050 2060 2070 2080 2090 2100
LPGTVEPPAS FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
2110 2120 2130 2140 2150 2160
IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG EKVVLWTREA
2170 2180 2190 2200 2210 2220
DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL MQLFHTACEA SSEDEDDATS
2230 2240
TSNADQLSDH GDLLSEEELD E
Protein Neighborhood
Domains & Features
5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q3T8J9-1-acetylation | MLPCKK... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
| Q3T8J9-1-acetylation | MLPCKK... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
| Q3T8J9-1-acetylation | MLPCKK... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162616 | ||
| Q3T8J9-1-acetylation | MLPCKK... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162617 | ||
| Q3T8J9-1-unknown | MLPCKK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q3T8J9-1-unknown | MLPCKK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt76211 | |||
| Q3T8J9-1-unknown | MLPCKK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt76212 | |||
| Q3T8J9-482- | SFQPMD... | 482 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
| Q3T8J9-482-unknown | SFQPMD... | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171678 | |||
| Q3T8J9-482-unknown | SFQPMD... | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171679 | |||
| Q3T8J9-954-unknown | RSLEKD... | 954 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12447 | |||
| Q3T8J9-954-unknown | RSLEKD... | 954 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157062 | |||
| Q3T8J9-954-unknown | RSLEKD... | 954 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157063 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...EINSDR | 953 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12447 | |||
| ...EINSDR | 953 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140556 | |||
| ...EINSDR | 953 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140557 | |||
| ...EELDE | 2241 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...EELDE | 2241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71830 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_HUMAN | 953 | NSDR.|.RSLE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|