Q53H96: Pyrroline-5-carboxylate reductase 3 {ECO:0000312|HGNC:HGNC:25846}

General Information

Protein names	- Pyrroline-5-carboxylate reductase 3 {ECO:0000312\|HGNC:HGNC:25846} - P5C reductase 3 - P5CR 3 - 1.5.1.2 {ECO:0000269\|PubMed:23024808} - Pyrroline-5-carboxylate reductase-like protein
Gene names	PYCRL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53H96

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH FQALGCRTTH
        70         80         90        100        110        120
SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS VAAGVSLSTL EELLPPNTRV
       130        140        150        160        170        180
LRVLPNLPCV VQEGAIVMAR GRHVGSSETK LLQHLLEACG RCEEVPEAYV DIHTGLSGSG
       190        200        210        220        230        240
VAFVCAFSEA LAEGAVKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT
       250        260        270
TIYGLHALEQ GGLRAATMSA VEAATCRAKE LSRK

Isoforms

- Isoform 2 of Pyrroline-5-carboxylate reductase 3

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q53H96-2-unknown	MAAAEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53H96-2-Acetylation	AAAEPS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53H96-2-Acetylation	AAAEPS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q53H96-2-Acetylation	AAAEPS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q53H96-2-Acetylation	AAAEPS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q53H96-223-unknown	EGQHPA...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7896

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KMLLHE	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7896
	...ELSRK	274	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	222	LLHE.\|.EGQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)