Q53QZ3: Rho GTPase-activating protein 15

General Information

Protein names	- Rho GTPase-activating protein 15 - ArhGAP15 - Rho-type GTPase-activating protein 15
Gene names	ARHGAP15
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53QZ3

12 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQKSTNSDTS VETLNSTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG KVTEPISRHR
        70         80         90        100        110        120
RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK NWSTSWIVLS SRRIEFYKES
       130        140        150        160        170        180
KQQALSNMKT GHKPESVDLC GAHIEWAKEK SSRKNVFQIT TVSGNEFLLQ SDIDFIILDW
       190        200        210        220        230        240
FHAIKNAIDR LPKDSSCPSR NLELFKIQRS SSTELLSHYD SDIKEQKPEH RKSLMFRLHH
       250        260        270        280        290        300
SASDTSDKNR VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHKVCERE NSTVPWFVKQ
       310        320        330        340        350        360
CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV VTGALKMFFR
       370        380        390        400        410        420
ELPEPLFPYS FFEQFVEAIK KQDNNTRIEA VKSLVQKLPP PNRDTMKVLF GHLTKIVAKA
       430        440        450        460        470
SKNLMSTQSL GIVFGPTLLR AENETGNMAI HMVYQNQIAE LMLSEYSKIF GSEED

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

12 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q53QZ3-1-unknown	MQKSTN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53QZ3-4-unknown	STNSDT...	4		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q53QZ3-4-	STNSDT...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q53QZ3-7-unknown	SDTSVE...	7		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q53QZ3-7-	SDTSVE...	7		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q53QZ3-43-unknown	SMILTD...	43		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q53QZ3-43-	SMILTD...	43		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q53QZ3-47-unknown	TDVGKV...	47		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q53QZ3-47-	TDVGKV...	47		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q53QZ3-49-unknown	VGKVTE...	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12458
Q53QZ3-77-	QLMVEK...	77		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q53QZ3-217-	SHYDSD...	217		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MILTDV	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12458
	...GSEED	475	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	48	LTDV.\|.VGKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)